200 Allergens as enzymes: Failure of HSA to protect degradation of grass allergens by mold extracts

Knöll, R.; Kagen, Steven L.; Muthiah, R.

doi:10.1016/0091-6749(91)91483-a

Cited by 6 publications

(1 citation statement)

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“…However, in practice, many researchers tend to mix allergen extracts from different biologic materials in their immunotherapy studies, even though their composition is only partially known, to simplify the administration. Otherwise, allergenic potency can diminish during storage, after dilution or by mixture with allergen extracts containing proteases [1][2][3][4], and the presence of these enzymes in allergen extracts has been well docu-mented [5][6][7]. Unfortunately, the loss in potency still affects the results of proper allergy diagnosis and immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

MALDI‐TOF MS analysis of labile Lolium perenne major allergens in mixes

Irañeta

Acosta

Durán

et al. 2008

Clin Experimental Allergy

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Lol p 1 and Lol p 5 degradation is responsible for the loss of the biological activity of L. perenne pollen extract when co-incubated with protease-rich fungal and cockroach extracts in the same vial for months in the absence of glycerol as a preserving agent. The integrity of these major allergens must be preserved to increase the vaccine stability and to assure efficacy when mixes are used for immunotherapy.

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Section: Introductionmentioning

confidence: 99%

MALDI‐TOF MS analysis of labile Lolium perenne major allergens in mixes

Irañeta

Acosta

Durán

et al. 2008

Clin Experimental Allergy

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Immunotherapy for Mold Allergy

Coop

2013

Clinic Rev Allerg Immunol

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The objective of this article is to review the available studies regarding mold immunotherapy. A literature search was conducted in MEDLINE to identify peer-reviewed articles related to mold immunotherapy using the following keywords: mold, allergy, asthma, and immunotherapy. In addition, references cited within these articles were also reviewed. Articles were selected based on their relevance to the topic. Allergic responses to inhaled mold antigens are a recognized factor in allergic rhinitis and asthma. There are significant problems with respect to the production of relevant allergen material for the diagnosis and treatment of mold allergy with immunotherapy. Mold allergens contain proteases and should not be mixed with other allergens for immunotherapy. Most of the immunotherapy studies focus on two molds, Alternaria and Cladosporium. There is a lack of randomized placebo-controlled trials when evaluating the efficacy of mold immunotherapy with trials only focusing on immunotherapy to Alternaria and Cladosporium. Additional studies are needed regarding mold allergy and immunotherapy focusing on which molds are important for causing allergic disease.

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