20 Years of Radiographic Imaging: Crystalline Deposits Causing Severe Arthropathy and Erosions

Abstract

Urate crystal gout arthritis and calcium pyrophosphate deposition disease (CPPD) are crystalline arthropathies seen in middle age to elderly patients, but are also seen in the active duty military population. Flares of either can be identified by acute joint pain, associated swelling, tenderness, and warmth. Definitive diagnosis involves synovial analysis from arthrocentesis. Gout and CPPD are common inflammatory joint diseases. Both arthropathies presenting themselves in the same joint are rather rare. An elderly female with a history of gout presented to the hospital with severe hip pain. She was on urate-lowering therapy at the time, and uric acid levels on admission were not significantly elevated. Radiographic imaging of her hip demonstrated periarticular cartilage calcifications. A review of radiographic imaging over the last 20 years found significant erosive arthropathy in multiple joints and radiographic evidence of chondrocalcinosis, suggesting CPPD. Synovial analysis was not obtained during this admission as the patient declined procedures due to her elderly age. Her condition improved with oral steroids. Few literatures have demonstrated that gout and CPPD are common crystal arthropathies that can occur concomitantly in the same joint. A 20-year review of imaging in an elderly female with known gout arthropathy found that she had radiographic evidence of concomitant CPPD-associated damage to many of her joints. Clinicians should be aware of the different erosive arthropathies, their corresponding imaging findings, evaluation for underlying metabolic disorders if appropriate, and the possibility that they may occur in the same joint. Early prevention can reduce joint destruction later in life.

Lucent Patellar Lesions: A Pictorial Review

“…findings (Figure 4A) include chondrocalcinosis (the calcification of fibrocartilage and hyaline cartilage), degenerative osteophytosis, joint space narrowing, and subchondral cystic change [20,22]. Prolonged disease may result in osseous erosions [23]. However, the presence of chondrocalcinosis is not specific for CPPD, and may be seen in a variety of diseases, including hyperparathyroidism, degenerative joint disease, gout, and diabetes mellitus [22].…”