The CNL manual establishes CultureNature Literacy (CNL) as Anthropocene competency in theory and practice. Numerous examples illustrate this innovative educational concept that focuses on cultural sustainability. The CNL manual is aimed at teachers in schools, colleges, universities, as well as student teachers who want to encourage learners – to acquire of fact-based knowledge of human-induced environmental change, – to understand nature and culture as a unity and therefore promote corresponding appreciation and shared responsibility, by using innovative didactic ways of teaching science, taking into account digitality, inclusion and participation, – to employ creative, critical, solution-oriented, (earth-)systemic thinking, – to develop ecological awareness and resilience to face the uncertainties of climate change, – to reflect on options for shaping the future in a value-based way. The CNL manual is complemented by next-practice examples for schools and universities that promote CultureNature Literacy as an Anthropocene competence: https://cnl.ph-noe.ac.at/