2  Synthetic methods : Part (ii) Oxidation and reduction methods

Biocatalysts suitable for the reduction of ketones bearing two sterically demanding substituents (bulky–bulky ketones) at elevated substrate concentration (10 g L–1) were identified. The biocatalysts can be employed in a substrate‐coupled approach; thus, a simple alcohol such as ethanol or 2‐propanol serves as a hydrogen donor. Both enantiomers are accessible by using either Rhodococcus ruber DSM 44541 and ethanol or Ralstonia sp. DSM 6428 and Sphingobium yanoikuyae DSM 6900 and ethanol or 2‐propanol as the hydrogen source. For Rhodococcus ruber DSM 44541, it was found that bulky–bulky ketones were only transformed when ethanol was used as a hydrogen source, whereas no conversion was observed when 2‐propanol was employed. From the substrate spectrum, as well as from the cosubstrate preference, it became clear that a different alcohol dehydrogenase than the previously described ADH‐“A” is active in the presence of ethanol in Rhodococcus ruber.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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Asymmetric reduction of 3-chloropropiophenone to (S)-3-chloro-1-phenylpropanol using immobilized Saccharomyces cerevisiae CGMCC 2266 cells

Yang

Yao

et al. 2009

Journal of Molecular Catalysis B: Enzymatic

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2 Synthetic methods : Part (ii) Oxidation and reduction methods

Cited by 3 publications

References 146 publications

Synthetic Methods. Part 2. Oxidation and Reduction Methods

Synthetic Methods. Part 2. Oxidation and Reduction Methods

Stereocomplementary Asymmetric Reduction of Bulky–Bulky Ketones by Biocatalytic Hydrogen Transfer

Asymmetric reduction of 3-chloropropiophenone to (S)-3-chloro-1-phenylpropanol using immobilized Saccharomyces cerevisiae CGMCC 2266 cells

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