2 Sustained release theophylline (SRT): Absorption in young children

Haltom, James R.; Szefler, Stanley J.

doi:10.1016/0091-6749(85)90137-x

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1989

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“…Halton and Szefier [8] treated asthmatic children, aged between 2 and 6 years, with two slow release theophylline products and verified similar serum theophylline levels, identical absorption, with adminis tration every 12 or 8 h. Despite receiving similar doses of the drug, the effectiveness was similar in these patients. We studied granule absorption after capsule opening, mixed with a viscous vehicle (honey).…”

Section: Discussionmentioning

confidence: 97%

Theophylline Serum Levels in Children with Bronchial Asthma after Administration of Slow Release Theophylline as Open or Closed Capsules

Naspitz

Solé²

1989

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Theophylline serum levels were studied after oral administration of slow release theophylline (Talofilina®) in children with bronchial asthma. The children received the drug as closed capsules or as granules, obtained by opening the capsules, for 1 week in each form. The mean dose used was 8.6 mg/kg every 12 h. The theophylline blood leves at 4, 8 and 12 h after drug ingestion were significantly lower when granules from open capsules were used. Our recommended dose of Talofilina for Brazilian children is 16 mg/kg/day, if administered as closed capsules, every 12 h. On open capsule administration every 12 h, the total daily recommended dose is 20 mg/kg/day.

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Section: Discussionmentioning

confidence: 97%