2‐Sulfonyliminodihydropyrimidines: A Novel Class of Analgesic Compounds

Abstract

A series of 2-sulfonyliminodihydropyrimidine derivatives have been synthesized and evaluated in vivo for their antinociceptive and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid. Compounds 6Ab-d and 6Be displayed an interesting analgesic profile in the acetic acid-induced abdominal contractions test. Based on the results of the carrageenan-hind paw edema test, compound 6Af showed potential anti-inflammatory activity.

Chloroquinoline–acetamide hybrids: a promising series of potential antiprotozoal agents

“…The product formed was recrystallized in ethanol (1-15). These compounds have already been reported in the following literature [24][25][26][27][28][29][30][31][32] For aliphatic (2-Chloro-acetamides): To a stirring solution of amine in 10 ml dichloromethane, triethylamine was added.…”

Síntese de novos fosfolipídios antitumorais para a inibição da enzima trifosfato de citidina (CTP)

“…A uma solução de 12b (0,100 mg, 0,6 mmol) em acetona (0,6 mL) foi adicionado iodeto de potássio (0,500 mg, 3,0 mmol). A reação ocorreu sob agitação e refluxo em um período de 8 horas, uma vez concluída, o solvente foi removido e o produto recuperado por recristalização em água deionizada (GONZÁLEZROSENDE et al, 2008). A formação do produto desejado foi confirmada através de espectrometria de massas (ESITOF).…”