2-Sulfobenzoic Acid Esters. I. 2-Sulfamyl Derivatives

Arylsulfonate-Based Nucleophile Assisting Leaving Groups

“…Poly(ethylene glycol)-containing arylsulfonyl chlorides 1 were prepared in good yields by treating sulfobenzoic acid anhydride with phosphorus pentachloride 8 followed by the addition of the methyl poly(ethylene glycol) unit (Scheme 1). Arylsulfonyl chlorides 1 were then reacted with 3-phenylpropanol to give the corresponding sulfonate esters 2 in yields ranging from 72 to 96%.…”

Synthesis of New Heterocyclic Mono- and Bisorganophosphorus Acids and Their Derivatives with 1,2-Phenylene Fragments

“…Anhydrides of phthalic and 2-sulfobenzoic acids readily react with various nucleophiles and are widely used in the organic and organometallic synthesis [9][10][11]. Previously, we had developed the convenient methods for the synthesis of the functionalized organophosphorus amides of iso-and terephthalic acids [12].…”

“…( 1, 1-Dioxido-3H -2, 1-benzoxathiol -3-yl ) phosphonic acid (10). Yield 96%, mp 70 • C. 1 Н NMR, δ, ppm: 6.07 (d, С 1 Н, 2 J PH = 8 Hz), 7.6-7.9 (m, С 6 Н 4 ).…”

Synthesis and Chemistry of 1,2,3-Benzothiadiazine 1,1-Dioxide Derivatives: A Comprehensive Overview

“…In 1962, Loev and Kormendy observed the formation of the 1,2,3,4-tetrahydro-1,2,3 -benzothiadiazine-1,1,4-trione (64) in the reaction of 2-chlorosulfonylbenzoic acid isopropyl ester 65a with hydrazine (Scheme 25) [51]. Almost fifty years later, Ramana and Reddy described the same synthesis, giving details for the preparation of starting compound 65a from saccharin (66) via 2-sulfobenzoic acid (67) and 2-chlorosulfonylbenzoyl chloride (68).…”