2-Substituted (S)-2-(3,3-dimethyl-1-oxo-10,10a-dihydroimidazo[1,5-b]isoquinolin-2(1H,3H,5H)-yl)acetic acids: Conformational prediction, synthesis, anti-thrombotic and vasodilative evaluation

Efficient one pot preparation of novel 1-oxo-3-aryl-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-2-carboxylic acid derivatives in a green solvent

“…14 Because the benzo [4,5]imidazo [1,2-a]pyridine scaffold show interesting biological activities, the synthesis of this group of compounds has been realised via several routes, including cycloaddition reactions, 6,9,15 condensation reactions, [16][17][18] multicomponent reactions, 10,[19][20][21][22][23] and multistep approaches. 5,[24][25][26] Also, metallic and non-metallic catalysts, [27][28][29][30] microwave irradiation, 31 and a series of transition metal catalysts have been used for the preparation of these compounds. 1,32 No doubt, the existing methods are useful, but also possess certain limitations such as an extended reaction time, special apparatus, high temperature, expensive catalysts, toxic solvents, and tedious workup processes.…”