2-Substituted Furans from the Roots of Polyalthia evecta

Abstract

Four new 2-substituted furans, 19-(2-furyl)nonadeca-5,7-diynoic acid (1), 19-(2-furyl)nonadeca-5-ynoic acid (2), 1-(2-furyl)pentacosa-7,9-diyne (3), and ester 21-(2-furyl)heneicosa-14,16-diyne-19-(2-furyl)nonadeca-5,7-diynoate (4) have been isolated from the roots of Polyalthia evecta. Their structures were established by spectroscopic techniques. Compounds 1 and 1a showed antiplasmodial activity. The acids 1 and 2 exhibited antiviral activity against Herpes simplex type 1. In addition, 5 also showed cytotoxicity against the NCI-H187 cell line.

Synergistic anticancer effect of the extracts from Polyalthia evecta caused apoptosis in human hepatoma (HepG2) cells

“…4 and an incidence angle of 45 暳 , yielding a total of six internal reflections at the sample. Spectra were recorded with a Tensor 27 FTIR spectrometer equipped with a KBr beam splitter and an MCT detector cooled with liquid nitrogen with a measurement range of 4 000-6 000 cm -1 .…”

“…The phytochemicals found in the hexane extraction of the root of P. evecta are evectic acid and furans [4] . The respective bioactive constituents from the hexane and dichloromethane extracts of the air-dried roots were shown to be active against Plasmodium falciparum and Mycobacterium tuberculosis [3] .…”

Anticancer effect of the extracts from Polyalthia evecta against human hepatoma cell line (HepG2)

“…The root of P. evecta has long been used, based on Thai local wisdom, as a carminative and as a galactagogue for inducing milk secretion in breastfeeding mothers [8,9] . The phytochemicals found in the hexane extract of the root of P. evecta are evectic acid and furans [8,9] .…”

“…The root of P. evecta has long been used, based on Thai local wisdom, as a carminative and as a galactagogue for inducing milk secretion in breastfeeding mothers [8,9] . The phytochemicals found in the hexane extract of the root of P. evecta are evectic acid and furans [8,9] . The respective bioactive constituents from the hexane and dichloromethane extracts of the air-dried roots were shown to be active against Plasmodium falciparum and Mycobacterium tuberculosis [8,9] .…”

“…The phytochemicals found in the hexane extract of the root of P. evecta are evectic acid and furans [8,9] . The respective bioactive constituents from the hexane and dichloromethane extracts of the air-dried roots were shown to be active against Plasmodium falciparum and Mycobacterium tuberculosis [8,9] . High higher than the positive control, melphalan (SI = 1.6) and the apoptotic cells (46.4 依 2.6) % induced by EW-L was higher than the melphalan (41.6 依 2.1)% (P<0.05).…”