2-[(Pyridin-3-ylamino)methyl]phenol

Abstract

In the title compound, C12H12N2O, the aromatic rings at either ends of the –CH2–NH– link are twisted by 68.79 (7)°. In the crystal, the hy­droxy substituent is a hydrogen-bond donor to the N atom of the pyridine ring of an adjacent mol­ecule, and the hydrogen bond generates a chain along the b axis; it is also a hydrogen-bond acceptor to the amino group of another adjacent mol­ecule. The two hydrogen bonds lead to the formation of a layer structure.

2-{[(Pyridin-2-yl)amino]methyl}phenol

“…Curiously, there are only few 2-(arylamino)methylphenols compared with the plethora of Schiff bases in the chemical literature. Among the aminopyridine derivatives, only the crystal structure of 2-((pyridin-3-ylamino)methyl)phenol has been reported (Xu et al, 2011). The 2-((pyridin-2-ylamino)methyl)phenol analog (Scheme I) has been described as its metal adducts only (Yalçın et al, 2007).…”

“…For 2-[(pyridin-3-ylamino)-methyl]phenol, see: Xu et al (2011). For the metal adducts of 2-[(pyridin-2-ylamino)methyl]phenol, see: Yalçın et al (2007).…”

2-[(Pyrimidin-2-ylamino)methyl]phenol

“…For the N-salicylidene-2-aminopyrimidine precursor, see: El-Haty et al (1990); Issa et al (2011); Shalabi & Abdel-Ghani (1990). For a related structure, see: Xu et al (2011).…”