2‐Propenal (Acrolein) [MAK Value Documentation in German language, 1997]

doi:10.1002/3527600418.mb10702d0025

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“…Genotoxic/mutagenic effects of AC have been reported at non-cytotoxic concentrations in bacterial test systems (US-EPA 2003). Data were not conclusive since depending on the strain and test conditions positive as well as negative results were observed (Irwin 2006;MAK-Commission 2012a).…”

Section: Characterisation Formation Occurrence and Public Health Concernmentioning

confidence: 99%

“…Hypoxanthine-guanine phosphoribosyltransferase mutations have been observed sporadically, e.g. in V79 cells, AC was found to be mutagenic in the mM concentration range but was later reported not to induce a significant mutagenic response in the presence or absence of metabolic activation (Irwin 2006;MAK-Commission 2012a;Parent et al 1991;SKLM 2013;Smith et al 1990). In HepG2 cells, AC induced DNA strand breaks (at 12.5 and 25 μM) and DNA-protein crosslinks (at 50-100 μM) (Li et al 2008).…”

Section: Characterisation Formation Occurrence and Public Health Concernmentioning

confidence: 99%

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The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment

et al. 2022

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The “totality” of the human exposure is conceived to encompass life-associated endogenous and exogenous aggregate exposures. Process-related contaminants (PRCs) are not only formed in foods by heat processing, but also occur endogenously in the organism as physiological components of energy metabolism, potentially also generated by the human microbiome. To arrive at a comprehensive risk assessment, it is necessary to understand the contribution of in vivo background occurrence as compared to the ingestion from exogenous sources. Hence, this review provides an overview of the knowledge on the contribution of endogenous exposure to the overall exposure to putative genotoxic food contaminants, namely ethanol, acetaldehyde, formaldehyde, acrylamide, acrolein, α,β-unsaturated alkenals, glycation compounds, N-nitroso compounds, ethylene oxide, furans, 2- and 3-MCPD, and glycidyl esters. The evidence discussed herein allows to conclude that endogenous formation of some contaminants appears to contribute substantially to the exposome. This is of critical importance for risk assessment in the cases where endogenous exposure is suspected to outweigh the exogenous one (e.g. formaldehyde and acrolein).

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Section: Characterisation Formation Occurrence and Public Health Concernmentioning

confidence: 99%

Section: Characterisation Formation Occurrence and Public Health Concernmentioning

confidence: 99%

The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment

et al. 2022

View full text Add to dashboard Cite

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2‐Propenal (Acrolein) [MAK Value Documentation in German language, 1997]

Abstract: Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 25. Lieferung, Ausgabe 1997 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfa… Show more

Cited by 1 publication

References 93 publications

The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment

The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment

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