2.	Prevalence of Extended spectrum beta- lactamase (ESBL) producing Klebsiella species and Escherichia coli among clinical isolates in a tertiary care hospital

Phamba, Sadaf Guldin; Saldanha, Dominic

doi:10.18320/jimd/201704.0106

Cited by 3 publications

(2 citation statements)

References 3 publications

(4 reference statements)

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“…Antimicrobial susceptibility testing of Klebsiella exhibited 100% resistance to Ampicillin. A previous study showed a similar resistance towards ampicillin (100%) that depicts Klebsiella species are intrinsically resistant to Ampicillin [12].…”

Section: Resultsmentioning

confidence: 60%

Antimicrobial Susceptibility Pattern of Klebsiella Species from Various Clinical Samples at a Tertiary Care Hospital

Sathyavathy

Madhusudhan

2020

JPRI

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The aim of the study was to investigate the antimicrobial susceptibility pattern of Klebsiella species from different clinical samples at Sree Balaji Medical College and Hospital, India. Overall 189 samples out of 980 non repetitive clinical samples obtained from wound/pus, urine, sputum swab and blood by disc diffusion method and identified as Klebsiella and analysed. Out of total 189 Klebsiella isolates, 76 out of 155 K. pneumoniae (49%) were resistant and none out of 34 Klebsiella oxytoca (0%) showed resistance to cefotaxime and ceftazidime by disc diffusion method. Antimicrobial susceptibility testing of Klebsiella exhibited 100% resistance to Ampicillin. The present study highlights the need for the continued monitoring of antimicrobial susceptibility patterns of important bacterial pathogens, so that rational antibiotic policies can be formulated.

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Section: Resultsmentioning

confidence: 60%

Antimicrobial Susceptibility Pattern of Klebsiella Species from Various Clinical Samples at a Tertiary Care Hospital

Sathyavathy

Madhusudhan

2020

JPRI

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“…Creating awareness on antibiotic resistance of organisms, designing and effective implementation of antibiotic policy are few steps to be taken towards handling resistant organisms (ESBL, MBL and AmpC producers) 22,23 . Regular microbiological surveillance is essential to know the prevalence of the these enzymes and their susceptibility pattern.…”

Section: Discussionmentioning

confidence: 99%

ESBL Producers in Gram Negative Isolates from Clinical Samples

Wadekar¹,

Sathish²,

Pooja³

et al. 2020

J Pure Appl Microbiol

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Resistance to beta lactam antibiotics is the most common cause for beta-lactamase production. Increasing number of extended spectrum beta-lactamase (ESBL) producers has reduced the treatment options which resulted in emergence of multidrug resistant strains, treatment failure and hence increased mortality. To detect phenotypically, ESBL producers in Gram negative isolates from different samples and to know their susceptibility pattern. A retrospective study of Gram negative isolates was conducted. Total of 521 isolates were isolated from various samples. They were processed and identified by standard procedures. The antibiotic susceptibility testing was performed by Kirby- Bauer disc diffusion method using CLSI guidelines. ESBL was detected by combination disk test. A total of 521 Gram negative isolates were isolated which included E. coli, Klebsiella pneumoniae, Citrobacter spp., Enterobacter spp., Proteus spp. and Acinetobacter spp. Pseudomonas aeruginosa. Of 521 isolates tested, ESBL was detected in 329 (63.1%) isolates. These isolates showed maximum susceptibility to piperacillin- tazobactam (86%) followed by imipenem (78.4%), amikacin (63.5%), cotrimoxazole (54.4%), ciprofloxacin (51%), amoxi-clav (44.9%), cefepime (44.1%), gentamicin (38.9%), cefoxitin (34.9%) and ampicillin (19.1%). ESBL producers which are resistant to beta lactam antibiotics have become a major problem. Detection of these beta-lactamase enzymes by simple disk method and its reporting will help clinicians in prescribing proper antibiotics.

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Association between Virulence Factors and Antimicrobial Resistance of Klebsiella pneumoniae Clinical Isolates from North Kerala

Kumaran¹,

Geetha²,

Baby³

2022

J. Pure Appl. Microbiol.

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Klebsiella pneumoniae is a common bacterial pathogen causes wide range of infections all over the world. The antimicrobial resistance of K. pneumoniae is a global concern and expresses several virulence factors contributing to the pathogenesis. The incidences of bacterial co-infection in viral pneumonia are common. Increased risk of K. pneumoniae co-infection in viral respiratory tract infection should be alerted in COVID-19 pandemic period. The study aims to detect the association between antimicrobial resistance and factors causing pathogenicity of K. pneumoniae. For the current study, 108 K. pneumoniae clinical isolates were included. Antimicrobial susceptibility test was done by Kirby-Bauer disc diffusion method according to CLSI guidelines. Virulence factors such as biofilm formation, haemagglutination, haemolysins, hypermucoviscocity, siderophore, amylase, and gelatinase production were determined by phenotypic method. In this study K. pneumoniae showed high level of antimicrobial resistance towards ampicillin (92.59%) followed by amoxicillin-clavulanic acid (67.59%) and cotrimoxazole (47,22%). An important association between biofilm formation and antimicrobial resistance was found to be statistically significant for cotrimoxazole (P-value 0.036) and amoxicillin-clavulanic acid (P-value 0.037). Other virulence factors like hypermucoviscocity, haemagglutination, amylase, and siderophore production were also showed a statistically significant relation (P-value <0.05) with antimicrobial resistance. Further molecular studies are necessary for the identification of virulence and antimicrobial resistance genes, for the effective control of drug-resistant bacteria.

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2. Prevalence of Extended spectrum beta- lactamase (ESBL) producing Klebsiella species and Escherichia coli among clinical isolates in a tertiary care hospital

Cited by 3 publications

References 3 publications

Antimicrobial Susceptibility Pattern of Klebsiella Species from Various Clinical Samples at a Tertiary Care Hospital

Antimicrobial Susceptibility Pattern of Klebsiella Species from Various Clinical Samples at a Tertiary Care Hospital

ESBL Producers in Gram Negative Isolates from Clinical Samples

Association between Virulence Factors and Antimicrobial Resistance of Klebsiella pneumoniae Clinical Isolates from North Kerala

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