2.P.362 Morning hypercoagulability and hypofibrinolysis: diurnal variations in circulating activated factor VII, prothrombin fragment F1+2, and plasmin-plasmin inhibitor-complex

Kapiotis, Stylianos; Jilma, Bernd; Quehenberger, Peter; Ruzicka, Katharina; Handler, Sylvia; Speiser, Wolfgang

doi:10.1016/s0021-9150(97)89001-6

Cited by 45 publications

(60 citation statements)

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“…In one study, the cohort included premenopausal and postmenopausal women together, and some of the women were using the oral contraceptive pill, which is recognized to increase F1 + 2 [29]. In two of the studies, the blood sample was collected at variable times during the day [12,14], yet there is recognized to be a diurnal rhythm of F1 + 2 [26,30], with F1 + 2 concentrations lower after 15.00 hours. Although it may be possible to statistically correct for the above factors, such correction was not performed in all studies.…”

Section: Discussionmentioning

confidence: 99%

Relationship of waist and hip circumference with coagulation and fibrinolysis in postmenopausal women

et al. 2007

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The contribution of obesity to the occurrence of cardiovascular events may not be wholly related to its influence on traditional risk factors. Coagulation and fibrinolysis may also influence cardiovascular risk, but the relationship of adiposity with these processes is unclear. The aim of the present study was to investigate the relationships of BMI (body mass index), waist circumference, hip circumference and WHR (waist-to-hip ratio) with VIIc (factor VII activity), plasma markers of thrombin generation [F1+2 (prothrombin fragment 1+2)], fibrin formation [SF (soluble fibrin)] and fibrin turnover (D-dimer), and PAI-1 (plasminogen activator inhibitor-1; a marker of fibrinolytic inhibitory capacity). The study cohort was 80 healthy postmenopausal women who were not diabetic, current smokers or taking hormone therapy and who had a fasting sample of blood collected. VIIc, F1+2, SF and PAI-1 were all positively correlated with BMI, waist circumference and WHR, whereas D-dimer was positively correlated with waist circumference and WHR, but not BMI. WHR was the strongest correlate of all the markers except for PAI-1, which was most closely related to BMI. Hip circumference became a negative correlate of F1+2 and D-dimer after adjusting for waist circumference. The relationships of WHR with F1+2 and SF, but not with VIIc and D-dimer, were independent of traditional risk factors. The positive association between waist circumference and markers of thrombin generation, fibrin production and fibrin turnover suggests that abdominal adiposity may contribute to atherothrombosis by activating intravascular coagulation. In contrast, a larger hip circumference appears to have a protective affect against coagulation activation.

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Section: Discussionmentioning

confidence: 99%

Relationship of waist and hip circumference with coagulation and fibrinolysis in postmenopausal women

et al. 2007

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“…PAI-1 and t-PA antigen were reported to have their lowest plasma levels in the late afternoon [30][31][32]. In contrast, Kapiotis et al [33] could demonstrate a morning hypercoagulability and hypofibrinolysis in healthy subjects since activated factor VII, F1 þ 2 and PAI-1 significantly decreased from 0800 to 2000 h. In our BUS-study, blood was collected between 1500 and 1600 h. By evaluating the possible influence of diurnal variations on plasma levels of F1 þ 2 we would have rather underestimated the peak increase in F1 þ 2 after bus travel. Changes in PAI-1 were of borderline significance, but the decrease in t-PA was highly significant in our study.…”

Section: Limitations Of the Studymentioning

confidence: 95%

Coagulation changes and edema formation during long-distance bus travel

Schobersberger¹,

Mittermayr²,

Innerhofer³

et al. 2004

Blood Coagulation &Amp; Fibrinolysis

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Long-distance travel in a cramped position by aircraft or by bus and car has been suggested to be associated with an increased risk for thromboembolic events. Recently, we demonstrated moderate activation of coagulation after a long-haul flight. At present the single contributing factors (i.e. hypoxia and low humidity on board an aircraft and prolonged sitting in an aircraft, car or bus inducing venous stasis) have not yet been investigated. Therefore we measured markers of coagulation and fibrinolysis as well as functional parameters of coagulation using activated thrombelastography in 19 healthy volunteers before, during and after a real 10-h bus journey. In addition, changes in leg volume were measured. Thrombelastography revealed moderate activation of coagulation in all travelers, which was accompanied by a significant increase in prothrombin fragment F1 + 2. Thrombin-antithrombin III complexes and D-dimer remained unchanged, and tissue-type plasminogen activator and plasminogen-activator inhibitor 1 decreased after travel. After the travel we found a significant increase in leg volume that was exclusively distributed in the calf. We conclude that beside long-haul flights also long-distance bus travel induces a certain activation of the coagulation system. Thus, it is questionable whether hypoxia is the crucial risk factor for thromboembolic events after long-haul flights.

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“…Spontaneous resolution of occlusions in coronary arteries [23], veins or even synthetic grafts [24,25] have has been reported in the past. Although these mechanisms appear to be rare or ineffective, recent surveys revealed that inadequate fibrinolytic activity, intensifies the severity and the frequency of coronary thromboembolic events [26][27][28]. Further study of this process and the incoming of a global test for it's measurement [29], will enable us a) to detect agents, among common used drugs, such as antidiabetics or antihypertensives that may hinder spontaneous fibrinolysis and b) to separate the patients, who suffer from coronary heart disease, into a high risk group that needs a more aggressive antiplatelet therapy [29].…”

Section: Discussionmentioning

confidence: 99%

Acute myocardial infarction and transient ischemic attack in a patient with lone atrial fibrillation and normal coronary arteries

Chlapoutakis

Kafkas

Katsanos

et al. 2010

International Journal of Cardiology

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2.P.362 Morning hypercoagulability and hypofibrinolysis: diurnal variations in circulating activated factor VII, prothrombin fragment F1+2, and plasmin-plasmin inhibitor-complex

Cited by 45 publications

References 0 publications

Relationship of waist and hip circumference with coagulation and fibrinolysis in postmenopausal women

Relationship of waist and hip circumference with coagulation and fibrinolysis in postmenopausal women

Coagulation changes and edema formation during long-distance bus travel

Acute myocardial infarction and transient ischemic attack in a patient with lone atrial fibrillation and normal coronary arteries

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