2-Methylsorbic acid, an antifungal metabolite of Penicillium vermiculatum

Proksa, B.; Adamcová, Jana; Fuska, J.

doi:10.1007/bf00180965

Cited by 10 publications

(3 citation statements)

References 7 publications

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“…Kim and Fravel (1990) showed that glucose oxidase produced by T. flavus prevented formation of microsclerotia of V. dahliae. However, Proksa et al (1992) showed that 2-methyl sorbic acid secreted by T. flavus showed an inhibitory effect on the growth of V. a.-a.…”

Section: Discussionmentioning

confidence: 99%

Biological Control of Tomato Verticillium Wilt Disease by Talaromyces Flavus

Naraghi¹,

Heydari²,

Rezaee³

et al. 2010

Journal of Plant Protection Research

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For comparison of the infection index in treatments, the greenhouse experiment was performed with a split plot arranged in a randomized complete block design with four replications. Result of greenhouse experiments on different types of T. flavus treatments indicated that there was no significant difference among them. However, among five T. flavus isolates, the most effective one was Tf-To-V-24 and Tf-To-U-36. In the experiment on the interaction between different T. flavus treatments and T. flavus isolates, a minimum infection index was observed when both soil and seed were treated with Tf-To-V-31. The overall results of this study show that it may be possible to manage tomato Verticillium wilt disease effectively by T. flavus.

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Section: Discussionmentioning

confidence: 99%

Biological Control of Tomato Verticillium Wilt Disease by Talaromyces Flavus

Naraghi¹,

Heydari²,

Rezaee³

et al. 2010

Journal of Plant Protection Research

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“…The acid subunit was previously found as an ester of an antifungal compound isolated from Graphium putredinis (Kennedy et al, 1998) and the above-mentioned antifungal isomer (2Z, 4E) was identified as a free acid from culture extracts of Penicillium vermiculatum (Proksa et al, 1992). It is noteworthy that, although the strain grew well in the same medium without artificial sea water and also in malt extract agar, the compounds were not produced, even at trace levels, under those conditions.…”

Section: Resultsmentioning

confidence: 91%

“…Nonetheless, the acid 6 and the ester 5 displayed the greatest antifungal activity, in the same order as benomyl, a commercial antifungal product. The natural (2Z, 4E) isomer of 6 was previously reported as an antifungal metabolite against other fungal strains (Proksa et al, 1992). Several isoleucine derivatives were previously isolated from different microbial strains as C-amides (Kern et al, 1985), esters (Iwamoto et al, 1990) or unknowns (Kawakami et al, 1978).…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial metabolites produced by an intertidal Acremonium furcatum

et al. 2006

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In a screening for antimicrobial metabolites, amides of D-allo- and L-isoleucine derivatives were isolated from the culture of a marine strain of Acremonium furcatum. Structural elucidation of these compounds was performed by analysis of spectroscopic data and confirmed by synthesis. All of the compounds, natural and synthetic intermediates, were bioassayed against bacteria and phytopathogenic fungi, with many showing remarkable antifungal activities.

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N‐Bearing Furanone Derivatives from an Endophytic Fungus in Huperzia serrata

Xiang

Shan

Liang

et al. 2013

Helvetica Chimica Acta

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Two new polyketide derivatives, huaspenones C and D (1 and 2, resp.), were isolated from the cultures of an endophytic fungus Peyronellaea sp. HS-12, derived from the stems of Huperzia serrata. They share N-bearing furan-3(2H)-one backbone, and 2 has an unprecedented furo[3,2-c]pyridine skeleton. Their structures including the absolute configuration were elucidated by extensive spectroscopic analysis combined with quantum-chemical calculations. (2E,4E)-6-hydroxy-2-methylocta-2,4dienoic acid (3), a key intermediate of the biosynthesis of 1 and 2, was also obtained from the endophyte.Introduction. -Endophytic fungi are microorganisms which spend their life cycle, as a whole or partly, colonizing inter-and/or intra-cellularly inside the healthy tissues of their host plant, typically causing no apparent symptoms of disease [1]. The research on endophytes showed that they are potential sources of novel biologically active secondary metabolites for exploitation in medicine, agriculture, and industry [2 -5]. Furthermore, results from many researches indicated that they could metabolize the same substance as their own host plants [6 -8], rendering them an alternative source of plant secondary metabolites.Huperzia serrata, a Chinese folk medicinal herb, is well-known for the discovery of hupzine A, a potent, highly specific, and reversible inhibitor of acetylcholinesterase [9] [10]. In a previous study, two new furan-3(2H)-one derivatives, huaspenones A and B (4 and 5, resp.), were isolated from Aspergillus sp. XW-12 derived from the stems of H. serrata [11] 1 ). In this work, two novel N-containing furan-3(2H)-one derivatives, 1 and 2, were isolated from the rice culture of an endophytic fungus Peyronellaea sp. HS-12 obtained from the stems of H. serrata, together with a key intermediate of the biosynthesis of 1 and 2, i.e., (2E,4E)-6-hydroxy-2-methylocta-2,4-dienoic acid (3). In addition, two known compounds, andrastin A (4) [13] and huaspenone B (5) [11], were also obtained from the endophytic fungus. Their structures were elucidated by NMR spectroscopy, especially 2D-NMR spectra. The absolute configurations of 1 and 2 were determined by CD analysis, combined with quantum-chemical calculation. To the best of our knowledge, huaspenones C and D (1 and 2, resp.) are the first examples of Nbearing furan-3(2H)-one derivatives in nature, and 2 has an unprecedented furo[3,2c]pyridine skeleton.

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2-Methylsorbic acid, an antifungal metabolite of Penicillium vermiculatum

Cited by 10 publications

References 7 publications

Biological Control of Tomato Verticillium Wilt Disease by Talaromyces Flavus

Biological Control of Tomato Verticillium Wilt Disease by Talaromyces Flavus

Antimicrobial metabolites produced by an intertidal Acremonium furcatum

N‐Bearing Furanone Derivatives from an Endophytic Fungus in Huperzia serrata

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