2-LED-µSpectrophotometer for Rapid On-Site Detection of Pathogens Using Noble-Metal Nanoparticle-Based Colorimetric Assays

Reuter, Cornelia; Urban, Matthias; Arnold, Manuel; Stránik, Ondrej; Csáki, Andrea; Fritzsche, Wolfgang

doi:10.3390/app10082658

Cited by 3 publications

(2 citation statements)

References 45 publications

(51 reference statements)

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“…reported in the literature. [263][264][265][266] Various scientific reports have also reported gold nanoparticle-based microfluidic devices as chemical-sensing agents (Cocaine, codeine, methamphetamine, cysteine, hemoglobin, etc., detection). [263,267,268] Notably, Ameku et al, reported a dual detection lab-on-chip device (Figure 17) by immobilizing GNPs for SERS and electrochemical sensing of cocaine for forensic application.…”

Section: Cytokine Flow and Severe Respiratory Syndromementioning

confidence: 99%

Gold nanoparticles (GNPs) in biomedical and clinical applications: A review

Anik

Mahmud²,

Masud

et al. 2021

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Gold nanoparticles (GNPs) have been extensively used in various applications ranging from environmental detection to biomedical applications. Due to their unique characteristics such as tunable surface properties as well as surface plasmon resonance (SPR), GNPs have garnered attention in various applications exclusively in therapy and diagnostics. Their ease of synthesis and compatibility with various functionalizing ligands has made them efficient and a robust biomedical platform. Due to their flexibility in synthesis and functionalization, GNPs have been profoundly used in cancer treatment as well as, antiviral, and antibacterial agents. In addition, owing to possessing unique optical properties, GNPs have been utilized as molecular imaging and contrast agent. This article discusses and highlights special characteristics of GNPs that have been exploited in biomedical applications in recent years to improve biomedical research in various biomedical field such as nuclear medicine, molecular imaging and contrast agent, vaccine development, medical implant, diagnostics, biosensing, and lab‐on‐chip applications. Moreover, their size dependent biocompatibility, biodistribution, and excreation was discussed in details for various in vivo applications. At the forefront of modern theraputic technology, GNPs based cancer treatment and antiviral agents have great potential which is also highlighted briefly in this article. In addition, current state of ongoing clinical trials and challenges associated with regulatory approval are explored. Lastly, the article sheds light on recent findings on the toxicity of GNPs and discusses the current challenges and prospects to future direct GNPs based biomedical research.

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Section: Cytokine Flow and Severe Respiratory Syndromementioning

confidence: 99%

Gold nanoparticles (GNPs) in biomedical and clinical applications: A review

Anik

Mahmud²,

Masud

et al. 2021

Nano Select

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“…5.3. Plasmonic Nanoparticles in DNA Amplification Assays C. Reuter et al [74] introduced a low-cost, simple prototype device (2-LED-µSpectrophotometer) for performing colorimetric DNA-amplification assay. The colorimetric sensing principle was based on salt or pH-induced aggregation of AuNPs, functionalized with oligonucleotides, which led to plasmon shift in the spectrum and solution color change.…”

Section: Paper-based Bioanalytical Systems Using Sensor Particlesmentioning

confidence: 99%

Sensor Micro and Nanoparticles for Microfluidic Application

Mazetyte‐Stasinskiene

Köhler

2020

Applied Sciences

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Micro and nanoparticles are not only understood as components of materials but as small functional units too. Particles can be designed for the primary transduction of physical and chemical signals and, therefore, become a valuable component in sensing systems. Due to their small size, they are particularly interesting for sensing in microfluidic systems, in microarray arrangements and in miniaturized biotechnological systems and microreactors, in general. Here, an overview of the recent development in the preparation of micro and nanoparticles for sensing purposes in microfluidics and application of particles in various microfluidic devices is presented. The concept of sensor particles is particularly useful for combining a direct contact between cells, biomolecules and media with a contactless optical readout. In addition to the construction and synthesis of micro and nanoparticles with transducer functions, examples of chemical and biological applications are reported.

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