2‐Ketophenyl Assisted Biomimetic Synthesis of 3‐Thio Substituted Glycals at Room Temperature
Irshad Ahmad Zargar,
Norein Sakander,
Debaraj Mukherjee
Abstract:Herein we designed a strategy for the synthesis of regioselective and stereoselective displacement of C‐3 acetate group in the presence of other C‐4 and C‐6 acetate of 2‐ketophenyl‐glycal by different aromatic and cyclic aliphatic thiol nucleophiles taking inspiration from cytosolic esterase mediated thiolation of glucosamine sugars into cellular glycan. Under a mild base condition at room temperature, the protocol generated a library of 3‐arylthiosugars with excellent yields and high axial selectivity. This s… Show more
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