2-Ketogluconic acid and pyrroloquinoline quinone secreting probiotic Escherichia coli Nissle 1917 as a dietary strategy against heavy metal induced damage in rats

Raghuvanshi, Ruma; Chaudhari, Archana; Archana, G.

doi:10.1016/j.jff.2017.08.013

Cited by 12 publications

(13 citation statements)

References 76 publications

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“…Notably, SCFAs were upregulated by colonic microbiota, which allowed the authors to propose that probiotics possess the Pb-against potential by regulating intestinal microbiome ( Zhai et al, 2019b ). Moreover, Raghuvanshi et al (2017) developed a transgenic probiotic that markedly prevented LPS-induced impairment in rats exposed to Pb, as well as recovered the normal absorption of essential metal ions. In a previous study, Tian et al (2012) firstly gave evidence that Lactobacillus plantarum CCFM8661 could bind Pb in vitro , and which also offered remarkable protective effects on hematology and oxidative stress in mice.…”

Section: Probiotics Treatment As a Promising Pb-against Strategymentioning

confidence: 99%

Pb Toxicity on Gut Physiology and Microbiota

et al. 2021

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Lead (Pb) is a toxic heavy metal, having profound threats to the global population. Multiple organs such as kidney, and liver, as well as nervous, hematologic, and reproductive systems, are commonly considered the targets of Pb toxicity. Increasing researches reported that the effects of Pb on gastrointestinal tracts are equally intensive, especially on intestinal microbiota. This review summarized Pb toxicity on gut physiology and microbiota in different animal models and in humans, of which the alterations may further have effects on other organs in host. To be more specific, Pb can impair gut barrier and increase gut permeability, which make inflammatory cytokines, immunologic factors, as well as microbial metabolites such as bile acids (BA) and short-chain fatty acids (SCFAs) enter the enterohepatic circulation easily, and finally induce multiple systematic lesion. In addition, we emphasized that probiotic treatment may be one of the feasible and effective strategies for preventing Pb toxicity.

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Section: Probiotics Treatment As a Promising Pb-against Strategymentioning

confidence: 99%

Pb Toxicity on Gut Physiology and Microbiota

et al. 2021

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“…EcN::vgb-gfp strain operon containing pqq gene cluster from Gluconobacter oxydans decreased the Cd and Hg toxicity upon oral supplementation citric acid due to the antioxidant effects of PQQ and chelation ability of citric acid [42]. Subsequently, EcN::vgb-gfp strain containing pqq gene cluster from A. calcoaceticus and gluconate dehydrogenase (gad) operon from Pseudomonas putida KT2440 secreted PQQ, gluconic and 2-ketogluconic acids, and this strain prevented toxicity caused by Cd, Hg and Pb without affecting the essential metal ions [43]. Thus, 2-ketogluconic acid produced by EcN recombinant strain is mimicking the chelating abilities of citric acid.…”

Section: Tablementioning

confidence: 99%

“…EcN recombinant strain containing pqq operon secretes 15 mM gluconic acid [43]. Gluconic acid was proposed for cancer therapy as cancer cells utilize citrate for growth and gluconic acid irreversibly inhibits citrate transporter, which is expressed on cancer cells [60].…”

Section: Tablementioning

confidence: 99%

Potential of Escherichia coli Probiotics for Improved Health and Disease Management

Archana¹

2023

Escherichia Coli - Old and New Insights

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Although natural gut microbiota containsEscherichia coli as a commensal, this bacterium, along with other members of the Enterobacteriaceae family, are usually known for their pathogenic potential. Interestingly, E. coli colonizes first and remains all through life, and in fact, some strains possess beneficial properties such as antibacterial colicin secretion. Among the beneficial strains, E. coli Nissle, isolated in 1917, has been the most extensively explored strain. Adaptability to survive under diverse conditions coupled with facile genetic manipulations enabled the design of E. coli strains with properties to deliver antioxidant, anti-inflammatory, and antitumor molecules. Moreover, genetically modified E. coli strains secreting enzymes for converting sucrose and fructose into insulin and mannitol, respectively, were very effective in preventing the onset of metabolic disease by acting as synbiotics. Thus, E. coli is emerging as a very potent probiotic platform for developing strains with the potential of controlling many metabolic and multifactorial diseases, including cancer.

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“…The majority of metals are concentrated in the liver and kidney, along with other essential organs, where they can have toxic or non-toxic effects such as oxidative stress, immunotoxicity, cardiotoxicity, teratogenicity, enzyme inhibition, birth abnormalities, and endocrine disruption [27]. Due to the wide range of chemical characteristics and toxic endpoints, the precise chemical basis of metal toxicity is poorly understood, and there is no universal mechanism for all dangerous metals [22].…”

Section: General Effects Of Heavy Metalsmentioning

confidence: 99%

“…Metals in their ionic form can interact with biological systems and toxicological targets in a variety of ways, making them chemically very reactive [14]. This can lead to a variety of toxic effects and damage to different organs, such as the kidney, nervous system, liver, respiratory system, endocrine and reproductive systems, and gastrointestinal tract (Table 2) [11,25,27]. Targets for heavy metals typically include biological molecules, macromolecules, membranes, or organelles, and interactions between free metal ions and these targets are what cause toxicity [29].…”

Section: General Effects Of Heavy Metalsmentioning

confidence: 99%

Heavy Metals’ Poisoning in Farm Animals

Acheampong

2023

Heavy Metals - Recent Advances

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Heavy metals are metallic elements with a high density compared to water that are found in trace amounts in a variety of matrices. Mercury poisoning can cause brain damage, skin damage, and increase risk of cancer development. Mercury-poisoned animals cannot produce meat, liver, or kidneys fit for human consumption. Heavy metals can cause cell dysfunction and toxicity by attaching to protein sites and displacing the original metals from their native binding sites. Reducing input/output ratio of heavy metals in animals should be the main objective of effective solutions. Electro-remediation involves running an electric current through liquid manure to cause metal ions to precipitate on an electrode.

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2-Ketogluconic acid and pyrroloquinoline quinone secreting probiotic Escherichia coli Nissle 1917 as a dietary strategy against heavy metal induced damage in rats

Cited by 12 publications

References 76 publications

Pb Toxicity on Gut Physiology and Microbiota

Pb Toxicity on Gut Physiology and Microbiota

Potential of Escherichia coli Probiotics for Improved Health and Disease Management

Heavy Metals’ Poisoning in Farm Animals

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