2 In vitro fertilization in the natural cycle

Lenton, Elizabeth A.; Cooke, I. D.; Hooper, M.A.K.; King, Helen; Kumar, Anju; Monks, Nicola J.; Turner, Kevin B.; Verma, Susheel

doi:10.1016/s0950-3552(05)80084-7

Cited by 33 publications

(11 citation statements)

References 16 publications

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“…This may be attributed to the milder hormonal conditions and because a better timing of ovum‐transfer is possible in the HRT cycles. Likewise, in natural cycle IVF, implantation may have a high chance of success 23 …”

Section: Implantation In Womenmentioning

confidence: 99%

Uterine Pinopodes in Peri‐implantation Human Endometrium Clinical Relevance

Nikas¹,

Psychoyos

1997

Annals of the New York Academy of Sciences

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Current clinical studies indicate the existence in the human of an "implantation/nidation window," similar to that observed in animal models. During this short period of uterine receptivity, the formation of pinopodes on the apical cell membrane of the endometrial epithelium is a consistent morphological event, observed in a number of species studies including the human. In order to develop a specific marker of the implantation window in clinical practice, we have investigated the kinetics of pinopode formation through sequential endometrial sampling under various hormonal conditions. Our results show that the implantation window in humans, according to this marker, lasts less than 48 hours, and the timing of its opening is dependent on the hormonal treatment applied, occurring earlier in cycles following ovarian stimulation and later in cycles induced by hormone replacement treatment. Furthermore, the timing varies among different individuals under the same treatment. These findings suggest that examination for pinopodes in endometrial samples can be highly useful in infertility treatment and research for the assessment of the nidation window on an individual basis. Our preliminary data strongly support the value of this assessment for better timing of ovum transfer, leading to an increase in implantation rates. Studies are now in progress on the expression of other endometrial signals present in relation to the pinopodes.

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Section: Implantation In Womenmentioning

confidence: 99%

Uterine Pinopodes in Peri‐implantation Human Endometrium Clinical Relevance

Nikas¹,

Psychoyos

1997

Annals of the New York Academy of Sciences

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“…Acceptable pregnancy rates in unstimulated cycles, comparable with natural fecundability of fertile couples, were reported in several groups (8,9). Relatively high preganacy rates per embryo transfer (20%) similar to natural fecundability were reported less frequently (2) than lower values (6,7).…”

Section: Introductionmentioning

confidence: 93%

“…In timing of oocyte pick up in unstimulated cycles for IVF, most authors apply the administration of human chorionic gonadotrophin (hCG) (4-7) or detection of natural LH surge (8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Untitled

Vlaisavljević

Kovačič

Reljič

et al. 2002

Journal of Assisted Reproduction and Genetics

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“…IUI was performed after 34-36 h with prepared semen using a Percoll preparation (Kabi Pharmacia AB, Uppsala, Sweden) in 80/40% concentration. However, if an LH surge occurred then timing of IUI with or without hCG was planned from worked out tables [15]. When an excessive response with more than 3 follicles occurred, the convertion to IVF was discussed with the patients.…”

Section: Protocol For Siuimentioning

confidence: 99%

Follow-Up of Patients with Unexplained Infertility Who Previously Underwent Natural Cycle in vitro Fertilization

Zayed¹

2000

Gynecol Obstet Invest

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One hundred and seventeen couples with unexplained infertility who underwent natural cycle in vitro fertilization (NIVF) in the years 1991–1993 at the Sheffield Fertility Centre (SFC) formed the basis of this analysis, where they were followed in the following years. Seventy-six of the 117 patients who did not conceive came back for further treatment and they were offered either stimulated intrauterine insemination (SIUI) or stimulated in vitro fertilization (SIVF). If fertilization was confirmed at NIVF they then received SIUI for three treatment cycles and a change to SIVF treatment. If fertilization was not confirmed at NIVF they were then subjected to SIVF. Only 41 patients out of 117 (35%) did not come back for further treatment. The remaining 76 patients (65%) had 130 cycles of treatment, 58 cycles of SIUI and 72 cycles of SIVF. An implantation rate of 23.4% per cycle completed was achieved in the SIUI group. The rate of implantation for the SIVF group was 19.4% per cycle completed. We conclude that patients with unexplained infertility who failed fertilization at NIVF showed fertilization and implantation at SIVF and SIUI, and the implantation rate was similar in both groups.

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2 In vitro fertilization in the natural cycle

Cited by 33 publications

References 16 publications

Uterine Pinopodes in Peri‐implantation Human Endometrium Clinical Relevance

Uterine Pinopodes in Peri‐implantation Human Endometrium Clinical Relevance

Untitled

Follow-Up of Patients with Unexplained Infertility Who Previously Underwent Natural Cycle in vitro Fertilization

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