2-Hydroxymethyl-18-crown-6 as an efficient organocatalyst for α - aminophosphonates synthesized under eco-friendly conditions, DFT, molecular docking and ADME/T studies

Abstract

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SB‐2 cationic resin: an efficient and reusable organocatalyst for the synthesis of α‐aminophosphonates, DFT calculations and, computer aided design in antifungal activity

“…Aromatic compounds bearing trimethoxy groups are known to exhibit good biological activities. [63][64] In order to highlight molecules with antifungal, we sought to incorporate the active substructural trimethoxy moiety into the backbone structure αaminophosphonate. Herein, we have scrutinized the four novel synthesized α-aminophosphonates (4 j, 4 k, 4 l and 4 m) in computational and theoretical studies such as quantum chemical calculations and modeling molecular study for molecular structured termination.…”

Box–Behnken design for the optimisation of Kabachnik–Fields reaction catalysed by natural kaolinite clay under eco-friendly conditions

“…19 In addition to transition metals, rare earths have also been used to synthesise these molecules; Jang et al developed a one-pot, three-component synthesis of α-aminophosphonates using Yb (OTf) 3 as a Lewis acid catalyst. 20 Brønsted acids have also been shown to catalyse the Kabachnik–Fields reaction, such as sulfamic acid, 21 binaphthyl-2,2′-diyl hydrogen phosphate, 22 crown ethers 23 and Fiaud's acid. 24 However, the use of Lewis or Brønsted acids encounters problems of relatively drastic synthesis and/or processing conditions and does not correspond to green chemistry conditions.…”