2-Hydroxy-4-methylselenobutanoic acid induces additional tissue selenium enrichment in broiler chickens compared with other selenium sources

Briens, Mickaël; Mercier, Yves; Rouffineau, Friedrich; Mercerand, Frederic; Geraert, P. A.

doi:10.3382/ps.2013-03182

Cited by 68 publications

(50 citation statements)

References 37 publications

(79 reference statements)

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“…In a comparison of the effect of OH-SeMet with that of sodium selenite and Se-yeast, all three Se sources increased muscle Se compared with control chickens, with a significant (P＜0.05) source effect in the order OH-SeMet＞Se-yeast＞ sodium selenite and the effect of OH-SeMet being 1.5-fold stronger than that of Se-yeast (Briens et al, 2014). Selenium speciation in tissues indicates that muscle Se is exclusively present as SeMet or SeCys, indicating a full conversion of OH-SeMet to active Se species in the bird.…”

Section: Oh-semetmentioning

confidence: 97%

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Selenium in Poultry Nutrition: from Sodium Selenite to Organic Selenium Sources

et al. 2018

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Selenium (Se) is an essential element in poultry nutrition and its bio-efficacy depends on its chemical form. A growing body of research proves that organic forms of Se, mainly selenomethionine (SeMet), in poultry diets have a range of important advantages over traditional sodium selenite. In fact, the organic Se concept considers SeMet as a storage form of Se in the chicken body. As chickens are not able to synthesize SeMet, its provision through diet is a key strategy to fight commercially relevant stresses. Indeed, in stress conditions, when increased selenoprotein expression requires additional Se, while its provision via feed usually decreases due to a reduction in feed consumption, Se reserves in the body (mainly in the muscles) could help maintain an effective antioxidant defense and prevent detrimental consequences of stresses. The poultry industry is looking for the most effective sources of organic Se for commercial use. In this review, advantages and disadvantages of main organic Se sources for poultry (Se-yeast, SeMet, and OH-SeMet) are analyzed, and future directions for the development of new Se sources are identified.

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Section: Oh-semetmentioning

confidence: 97%

“…Recently, a new organic Se source, OH-SeMet (2-hydroxy-4-melhylselenobutanoic acid or HMSeBA), has been developed (Briens et al, , 2014. It is a precursor of SeMet and after its dietary consumption, OH-SeMet is easily converted into SeMet and metabolized in the same way as pure SeMet, including building Se reserves in muscles.…”

Section: Oh-semetmentioning

confidence: 99%

Selenium in Poultry Nutrition: from Sodium Selenite to Organic Selenium Sources

et al. 2018

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“…Two principal forms of Se are currently used: inorganic Se, such as sodium selenite (SS) or sodium selenite, and organic Se, such as selenium yeast (SY). Many previous studies have shown that SY, the most widely used organic Se feed supplementation, has higher bioavailability (Briens et al, 2014) and is associated with a larger increase in Se in milk (Givens et al, 2004) and blood (Walker et al, 2010) and a greater improvement in antioxidant status (Gong et al, 2014;Sun et al, 2017).…”

Section: Short Communicationmentioning

confidence: 99%

“…Hydroxy-selenomethionine (HMSeBA) contains the active compound 2-hydroxy-4-methylselenobutanoic acid. It was approved for use as a new source of organic Se in some countries in 2013 (EFSA, 2013), and several studies have been published regarding effects of HMSeBA supplementation on growth performance and Se concentration in monogastric animals (Briens et al, , 2014Jlali et al, 2013). In ruminants, our previous study showed that HMSeBA could replace SS in the diet of dairy cows because it was more effective at improving antioxidant status and Se concentrations in plasma and milk than SS (Sun et al, 2017).…”

Section: Short Communicationmentioning

confidence: 99%

Short communication: Effects of different selenium supplements on rumen fermentation and apparent nutrient and selenium digestibility of mid-lactation dairy cows

Wei

Wang

Liu

et al. 2019

Journal of Dairy Science

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The aim of this study was to evaluate the dosedependent effects of a hydroxy-analog of selenomethionine (HMSeBA) on rumen fermentation, apparent nutrient digestibility, and total selenium absorption in mid-lactation dairy cows, and to compare the effects with those of sodium selenite (SS). Fifty mid-lactation dairy cows with similar milk yields, days in milk, and parity were randomly assigned to 1 of 5 treatments according to a randomized complete block design. The cows were fed a basal diet containing 0.06 mg/kg dry matter (DM) of Se (control) or the same basal diet supplemented with SS, yielding 0.3 mg of Se/kg of DM (SS-0.3), or HMSeBA, yielding 0.1, 0.3, or 0.5 mg of Se/ kg of DM (SO-0.1, SO-0.3, and SO-0.5, respectively), during the experimental period. The final content of Se in control, SS-0.3, SO-0.1, SO-0.3, and SO-0.5 was 0.06, 0.34, 0.15, 0.33, and 0.52 mg of Se/kg of DM.The experiment lasted for 10 wk, with a pretrial period of 2 wk. Supplementation with HMSeBA altered rumen fermentation by linearly increasing total volatile fatty acids and the molar proportions of propionate and butyrate but decreasing rumen pH, ammonia content, and the ratio of acetate to propionate. Compared with SS, HMSeBA enhanced the molar proportion of propionate in the rumen and the apparent digestibility of crude protein, neutral detergent fiber, acid detergent fiber, and selenium. We demonstrated that HMSeBA promoted rumen fermentation, apparent nutrient digestibility, and selenium absorption, implying that HMSeBA has a greater apparent absorption than SS.

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“…Based on:Mahan and Parrett, 1996; Mahan et al, 1999; Mateo et al, 2007;Svoboda et al, 2009; Kawecka et al, 2013; Jlali et al, 2014. (b): Based on:Skřivan et al, 2008;Petrovic et al, 2010; Hu et al, 2012;Ryzner et al, 2013;Chen et al, 2013;Briens et al, 2014. (c): Based on: Juniper et al, 2011.…”

mentioning

confidence: 99%

Scientific Opinion on the safety and efficacy of selenium compounds (E8) as feed additives for all animal species: sodium selenite (coated granulated preparation), based on a dossier submitted by Doxal Italia S.p.A

2015

EFS2

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Scientific Opinion on the safety and efficacy of selenium compounds (E8) as feed additives for all animal species: sodium selenite (coated granulated preparation), based on a dossier submitted by Doxal Italia S.p.A. ABSTRACTSelenium is a trace element that is essential for vertebrates and involved in a series of vital metabolic functions. The additive, a coated granulated preparation of sodium selenite, consists of carrier granules to which the active compound, sodium selenite, is fixed using filming agents; it is manufactured with different selenium contents. Sodium selenite is considered to be a safe source of selenium for all animal species/categories, also when applied in coated granulated preparations. Based on extensive published literature data, the use of sodium selenite as a source of selenium in animal nutrition is considered to be safe for the consumer, provided that the total maximum authorised content of selenium in complete feed is respected. No concerns would arise from inhalation of selenium during the handling of the coated granulated preparation of sodium selenite owing to the very low estimated exposure. The coated granulated preparation of sodium selenite is considered to be an irritant to the skin, eyes and the respiratory system, and a skin sensitizer. Systemic exposure to selenium could result from dermal contact, particularly when cutaneous absorption of sodium selenite might be facilitated by skin damage; any dermal contact with the additive should be avoided. The use of sodium selenite in animal nutrition up to the maximum authorised content in feed would not raise concerns regarding the soil compartment, the ground or surface water. Concerning the marine sediments, given standard aquaculture practices and the low potential maximum concentration of selenium from fish feeds, any impact on the environment is unlikely. The coated granulated preparation of sodium selenite is an efficacious source of the essential trace element selenium for all animal species.

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2-Hydroxy-4-methylselenobutanoic acid induces additional tissue selenium enrichment in broiler chickens compared with other selenium sources

Cited by 68 publications

References 37 publications

Selenium in Poultry Nutrition: from Sodium Selenite to Organic Selenium Sources

Selenium in Poultry Nutrition: from Sodium Selenite to Organic Selenium Sources

Short communication: Effects of different selenium supplements on rumen fermentation and apparent nutrient and selenium digestibility of mid-lactation dairy cows

Scientific Opinion on the safety and efficacy of selenium compounds (E8) as feed additives for all animal species: sodium selenite (coated granulated preparation), based on a dossier submitted by Doxal Italia S.p.A

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