2 Examination of Burn Resuscitation Complications from the Burn Navigator Observational Trial

Abstract

Introduction Burn care continues to focus on providing enough fluid resuscitation to perfuse end organs with the least amount of fluid necessary in order to prevent complications related to excess fluid. In this observational trial of 5 ABA-verified burn centers that utilized the Burn Navigator (BN), a clinical decision support tool, we sought to examine resuscitation-related complications that occurred in the first 48 hours after burn injury. Since minimal literature exists regarding the incidence of resuscitation-related complications in the acute phase after burn injury, we aimed to present our data for future comparison. Methods An observational study of adult patients undergoing burn resuscitation utilizing the BN was conducted. Data were gathered hourly for the first 48 hours for patients on fluid infusion rates, laboratory data, critical care elements to include ventilator settings and clinically relevant outcomes. Morbidities were classified based on each burn center’s definition as related to over or under-resuscitation and variables associated with these outcomes were extracted from the data set. Results Three hundred patients were enrolled into the study, and 156 resuscitation-related complications were documented in 92 patients in the first 48 hours after admission. Compartment syndromes (abdominal, extremity, ocular) accounted for 62 (40%) of the complications. ARDS occurred in 9 patients. ARDS patients were the most severely injured, reflected by highest Baux score. None of the ARDS patients had an inhalation injury. The under-resuscitation morbidities of shock and acute kidney injury accounted for 81 (52%) of the complications. Patients experiencing shock received greater than the Parkland formula in the first 24 hours after injury. Most patients with AKI continued to make adequate urine during their resuscitation period, with 59% making an average of >30 ml/hr over the first 24 hours. Nearly half of patients with AKI were placed on renal replacement therapy in the first 48 hours. Seventeen patients (18.5%) experienced both a compartment syndrome and either AKI or shock. Conclusions This large observational study demonstrates variables associated with different complications across 5 major burn centers and shows that complications associated with over- and under-resuscitation can occur within the same patient during resuscitation after burn injury. Additional comparative studies are needed to better understand the cause of these complications, to determine the incidence of these complications in a larger population and criteria used to define each complication.

Comparison between XGboost model and logistic regression model for predicting sepsis after extremely severe burns

“…Indeed, admission time following a burn injury is an important risk factor, and timely treatment of a burn injury, including effective fluid resuscitation, anti-shock therapy, early burn wound management, infection control, and organ protection, is important in preventing sepsis. 22,23…”

“…Indeed, admission time following a burn injury is an important risk factor, and timely treatment of a burn injury, including effective fluid resuscitation, anti-shock therapy, early burn wound management, infection control, and organ protection, is important in preventing sepsis. 22,23 Fibrinogen is a protein in the liver composed of three pairs of peptide chains, and plays an important role in the coagulation/ anticoagulation process. Fibrinogen is critical for blood clotting, and when its level is elevated, it may increase blood coagulation and become an important risk factor for thrombotic disease.…”