2-Deoxyglucose uptake in the rat visual system following pupil dilation with atropine

Rooney, B.J.; Cooper, R. M.

doi:10.1016/0042-6989(88)90153-8

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…Our results are unlikely to be associated with variations in pupil dilation as a result of luminance manipulations. Previous studies did not find differences in the retinotopic distribution of visual cortical activity after changes in pupil dilation (Haynes et al, 2004;Rooney & Cooper, 1988). The finding of a correlate of brightness induction that was stronger in V2 than in V1 is in agreement with a number of other studies that have used other paradigms to manipulate brightness of neighboring stimulus surfaces of identical luminance.…”

Section: Discussionsupporting

confidence: 87%

Early Human Visual Cortex Encodes Surface Brightness Induced by Dynamic Context

Ven

Jans

Goebel

et al. 2012

Journal of Cognitive Neuroscience

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Visual scene perception owes greatly to surface features such as color and brightness. Yet, early visual cortical areas predominantly encode surface boundaries rather than surface interiors. Whether human early visual cortex may nevertheless carry a small signal relevant for surface perception is a topic of debate. We induced brightness changes in a physically constant surface by temporally modulating the luminance of surrounding surfaces in seven human participants. We found that fMRI activity in the V2 representation of the constant surface was in antiphase to luminance changes of surrounding surfaces (i.e., activity was in-phase with perceived brightness changes). Moreover, the amplitude of the antiphase fMRI activity in V2 predicted the strength of illusory brightness perception. We interpret our findings as evidence for a surface-related signal in early visual cortex and discuss the neural mechanisms that may underlie that signal in concurrence with its possible interaction with the properties of the fMRI signal.

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Section: Discussionsupporting

confidence: 87%

Early Human Visual Cortex Encodes Surface Brightness Induced by Dynamic Context

Ven

Jans

Goebel

et al. 2012

Journal of Cognitive Neuroscience

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“…In these studies, we found that several regions, especially the dopaminergic system, had elevated 2-DG uptake after long-term amphetamine administration. Clozapine, which has a weak dopaminergic blocking effect, exhibits potent serotonergic, muscarinic and adrenergic antagonist activity, which may account for the general reduction of 2-DG uptake in this study, since these properties have been associated with the reduction of 2-DG uptake [13][14][15]. 2-DG uptake was reduced in fewer regions after longterm 20 mg/kg clozapine treatment (46%) than after acute 20 mg/kg clozapine treatment (97%).…”

Section: Discussionmentioning

confidence: 82%

Reduced Regional [<sup>14</sup>C]2-Deoxyglucose Uptake in Response to Long-Term Clozapine Administration in Rats

Tsai

Huang²,

Huang

et al. 2001

Neuropsychobiology

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Clozapine has superior effects in treating negative symptoms of schizophrenia and causes less extrapyramidal side effects than traditional antipsychotics. In this study, we investigated the effects of acute and long-term clozapine administration on [¹⁴C]2-deoxyglucose uptake (2-DG uptake) in rats, as measured using the [¹⁴C]2-deoxy-D-glucose method. The 2-DG uptake was reduced in fewer regions after chronic clozapine (46%) than after acute clozapine (97%). After chronic clozapine treatment, the 2-DG uptake was reduced in the shell, but not the core, of the nucleus accumbens. In addition, long-term clozapine treatment remained affecting 2-DG uptake in several regions of the extrapyramidal system and the thalamus. The pattern of 2-DG uptake changes after long-term clozapine administration may provide information for the regions related to the therapeutic effect of clozapine.

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Section: Discussionsupporting

confidence: 89%

Mechanisms of surface perception uncovered by visual illusions

Jans

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2-Deoxyglucose uptake in the rat visual system following pupil dilation with atropine

Cited by 3 publications

References 21 publications

Early Human Visual Cortex Encodes Surface Brightness Induced by Dynamic Context

Early Human Visual Cortex Encodes Surface Brightness Induced by Dynamic Context

Reduced Regional [<sup>14</sup>C]2-Deoxyglucose Uptake in Response to Long-Term Clozapine Administration in Rats

Mechanisms of surface perception uncovered by visual illusions

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