2′‐Deoxy‐2′‐α‐C‐(hydroxymethyl)adenosine as Potential anti‐HCV Agent

Abstract

Because of the importance of C‐branched nucleosides in the discovery of new antiviral molecules, we decided to synthesize 2′‐deoxy‐2′‐α‐C‐(hydroxymethyl)adenosine as a potential anti‐HCV agent. The synthesis of a new adenosine analogue following two different synthetic routes is described. The new C‐branched nucleoside was tested for its antiviral activity and found to be inactive.