2-D Strain Assessment in the Mouse Through Spatial Compounding of Myocardial Velocity Data: In Vivo Feasibility

Kremer, Florence; Dresselaers, Tom; Heyde, Brecht; Ferferieva, Vesselina; Caluwé, Ellen; Choi, Hon Fai; Claus, Piet; Oosterlinck, Wouter; Janssens, Stefan; Himmelreich, Uwe; D'hooge, Jan

doi:10.1016/j.ultrasmedbio.2013.04.004

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…In small animal studies [ 27 , 28 ] where the rapid heart rate and the small size of the heart require both high spatial and temporal resolutions, strain assessment by speckle tracking has been shown to be feasible using conventional echocardiography systems (GE, probe i13L-14Mhz), and helpful for detecting regional left ventricular dysfunction [ 28 ]. Reant et al [ 29 ] have also demonstrated the potential feasibility and utility of speckle tracking-strain during stress conditions in a large animal model as well.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of speckle tracking in the context of stress echocardiography in short axis view: An in vitro validation study

Hodžić¹,

Chayer²,

Wang³

et al. 2018

PLoS ONE

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AimThis study aimed to test the accuracy of a speckle tracking algorithm to assess myocardial deformation in a large range of heart rates and strain magnitudes compared to sonomicrometry.Methods and resultsUsing a tissue-mimicking phantom with cyclic radial deformation, radial strain derived from speckle tracking (RS-SpT) of the upper segment was assessed in short axis view by conventional echocardiography (Vivid q, GE) and post-processed with clinical software (EchoPAC, GE). RS-SpT was compared with radial strain measured simultaneously by sonomicrometers (RS-SN). Radial strain was assessed with increasing deformation rates (60 to 160 beats/min) and increasing pulsed volumes (50 to 100 ml/beat) to simulate physiological changes occurring during stress echocardiography. There was a significant correlation (R2 = 0.978, P <0.001) and a close agreement (bias ± 2SD, 0.39 ± 1.5%) between RS-SpT and RS-SN. For low strain values (<15%), speckle tracking showed a small but significant overestimation of radial strain compared to sonomicrometers. Two-way analysis of variance did not show any significant effect of the deformation rate. For RS-SpT, the feasibility was excellent and the intra- and inter-observer variability were low (the intraclass correlation coefficients were 0.96 and 0.97, respectively).ConclusionsSpeckle tracking demonstrated a good correlation with sonomicrometry for the assessment of radial strain independently of the heart rate and strain magnitude in a physiological range of values. Though speckle tracking seems to be a reliable and reproducible technique to assess myocardial deformation variations during stress echocardiography, further studies are mandated to analyze the impact of angulated and artefactual out-of-plane motions and inter-vendor variability.

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Section: Discussionmentioning

confidence: 99%

Accuracy of speckle tracking in the context of stress echocardiography in short axis view: An in vitro validation study

Hodžić¹,

Chayer²,

Wang³

et al. 2018

PLoS ONE

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Longitudinal observations of progressive cardiac dysfunction in a cardiomyopathic animal model by self-gated cine imaging based on 11.7-T magnetic resonance imaging

Saito

Tanoue

Masuda

et al. 2017

Sci Rep

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The purpose of this study was to longitudinally assess left ventricular function and wall thickness in a hamster model of cardiomyopathy using 11.7-T magnetic resonance imaging (MRI). MRI were performed for six cardiomyopathic J2N-k hamsters and six J2N-n hamsters at 5, 10, 15, and 20 weeks of age. Echocardiography was also performed at 20 weeks. The ejection fraction (EF) at 15 and 20 weeks of age in J2N-k hamsters showed a significant decrease compared with those in controls. Conversely, the end-systolic and end-diastolic volumes in cardiomyopathic hamsters showed a significant increase compared with those in controls. Moreover, the heart walls of J2N-k hamsters at 15 and 20 weeks were thicker than those of controls at end-systole; however, there were no significant differences at end-diastole. Optical microscopy with Masson’s trichrome staining depicted no fibrosis in the control myocardium, although it showed interstitial fibrosis in the 20-week-old J2N-k cardiomyopathic myocardium. There were no differences in EF and the wall thickness observed on MRI and those observed on echocardiography. These results indicate the presence of systolic dysfunction in cardiomyopathic hamsters. Self-gated cine imaging based on 11.7-T MRI can be used for serial measurements of cardiac function and wall thickness in a cardiomyopathic model.

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2-D Strain Assessment in the Mouse Through Spatial Compounding of Myocardial Velocity Data: In Vivo Feasibility

Cited by 2 publications

References 30 publications

Accuracy of speckle tracking in the context of stress echocardiography in short axis view: An in vitro validation study

Accuracy of speckle tracking in the context of stress echocardiography in short axis view: An in vitro validation study

Longitudinal observations of progressive cardiac dysfunction in a cardiomyopathic animal model by self-gated cine imaging based on 11.7-T magnetic resonance imaging

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