2-D Feasibility Study of Joint Reconstruction of Attenuation and Activity in Limited Angle TOF-PET

Vergara, Marina; Rezaei, Ahmadreza; Schramm, Georg; Rodríguez-Álvarez, M. J.; Baviera, José María Benlloch

doi:10.1109/trpms.2021.3079462

Cited by 2 publications

(1 citation statement)

References 29 publications

(35 reference statements)

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“…Moreover, prior information regarding the tracer distribution, such as known amount of activity in the FOV, needs to be provided, which might be impractical in clinical practice. However, promising results were provided when applied on brain data with errors lower than 4% [ 149 ] and good performance even in systems with limited FOV [ 150 ].…”

Section: Emission-based Attenuation Correctionmentioning

confidence: 99%

A review of PET attenuation correction methods for PET-MR

Krokos,

MacKewn,

Dunn

et al. 2023

EJNMMI Phys

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Despite being thirteen years since the installation of the first PET-MR system, the scanners constitute a very small proportion of the total hybrid PET systems installed. This is in stark contrast to the rapid expansion of the PET-CT scanner, which quickly established its importance in patient diagnosis within a similar timeframe. One of the main hurdles is the development of an accurate, reproducible and easy-to-use method for attenuation correction. Quantitative discrepancies in PET images between the manufacturer-provided MR methods and the more established CT- or transmission-based attenuation correction methods have led the scientific community in a continuous effort to develop a robust and accurate alternative. These can be divided into four broad categories: (i) MR-based, (ii) emission-based, (iii) atlas-based and the (iv) machine learning-based attenuation correction, which is rapidly gaining momentum. The first is based on segmenting the MR images in various tissues and allocating a predefined attenuation coefficient for each tissue. Emission-based attenuation correction methods aim in utilising the PET emission data by simultaneously reconstructing the radioactivity distribution and the attenuation image. Atlas-based attenuation correction methods aim to predict a CT or transmission image given an MR image of a new patient, by using databases containing CT or transmission images from the general population. Finally, in machine learning methods, a model that could predict the required image given the acquired MR or non-attenuation-corrected PET image is developed by exploiting the underlying features of the images. Deep learning methods are the dominant approach in this category. Compared to the more traditional machine learning, which uses structured data for building a model, deep learning makes direct use of the acquired images to identify underlying features. This up-to-date review goes through the literature of attenuation correction approaches in PET-MR after categorising them. The various approaches in each category are described and discussed. After exploring each category separately, a general overview is given of the current status and potential future approaches along with a comparison of the four outlined categories.

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Section: Emission-based Attenuation Correctionmentioning

confidence: 99%

A review of PET attenuation correction methods for PET-MR

Krokos,

MacKewn,

Dunn

et al. 2023

EJNMMI Phys

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Time of Flight in Perspective: Instrumental and Computational Aspects of Time Resolution in Positron Emission Tomography

Schaart

Schramm

Surti

2021

IEEE Trans. Radiat. Plasma Med. Sci.

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The first time-of-flight positron emission tomography (TOF-PET) scanners were developed as early as in the 1980s. However, the poor light output and low detection efficiency of TOF-capable detectors available at the time limited any gain in image quality achieved with these TOF-PET scanners over the traditional non-TOF PET scanners. The discovery of LSO and other Lu-based scintillators revived interest in TOF-PET and led to the development of a second generation of scanners with high sensitivity and spatial resolution in the mid-2000s. The introduction of the silicon photomultiplier (SiPM) has recently yielded a third generation of TOF-PET systems with unprecedented imaging performance. Parallel to these instrumentation developments, much progress has been made in the development of image reconstruction algorithms that better utilize the additional information provided by TOF. Overall, the benefits range from a reduction in image variance (SNR increase), through allowing joint estimation of activity and attenuation, to better reconstructing data from limited angle systems. In this work, we review these developments, focusing on three broad areas: (1) timing theory and factors affecting the time resolution of a TOF-PET system, (2) utilization of TOF information for improved image reconstruction, and (3) quantification of the benefits of TOF compared to non-TOF PET. Finally, we offer a brief outlook on the TOF-PET developments anticipated in the short and longer term. Throughout this work, we aim to maintain a clinically-driven perspective, treating TOF as one of multiple (and sometimes competitive) factors that can aid in the optimization of PET imaging performance.

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2-D Feasibility Study of Joint Reconstruction of Attenuation and Activity in Limited Angle TOF-PET

Cited by 2 publications

References 29 publications

A review of PET attenuation correction methods for PET-MR

A review of PET attenuation correction methods for PET-MR

Time of Flight in Perspective: Instrumental and Computational Aspects of Time Resolution in Positron Emission Tomography

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