2‐Butanone

Hoell, Detlef; Mensing, Thomas; Roggenbuck, Rafael; Sakuth, Michael; Sperlich, Egbert; Neier, Wilhelm; Strehlke, Guenter

doi:10.1002/14356007.a04_475.pub2

Cited by 13 publications

(11 citation statements)

References 15 publications

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“…2-Butanone is an important ketone, being widely used as a raw material in different industries, such as the paints, coatings, resins, and printing industries. For a long time it has been associated with some toxicity, but since 2005, it has been reclassified as a non-hazard air pollutant [ 187 ]. 2-Butanone occurs naturally in the environment, although in negligible levels when compared with its industrial demands, being secreted from many different species of bacteria, fungi, and plants ([ 188 , 189 , 190 , 191 , 192 , 193 , 194 ]).…”

Section: The Metabolics Of Eb Volatilesmentioning

confidence: 99%

Breath Analysis as a Potential and Non-Invasive Frontier in Disease Diagnosis: An Overview

et al. 2015

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Currently, a small number of diseases, particularly cardiovascular (CVDs), oncologic (ODs), neurodegenerative (NDDs), chronic respiratory diseases, as well as diabetes, form a severe burden to most of the countries worldwide. Hence, there is an urgent need for development of efficient diagnostic tools, particularly those enabling reliable detection of diseases, at their early stages, preferably using non-invasive approaches. Breath analysis is a non-invasive approach relying only on the characterisation of volatile composition of the exhaled breath (EB) that in turn reflects the volatile composition of the bloodstream and airways and therefore the status and condition of the whole organism metabolism. Advanced sampling procedures (solid-phase and needle traps microextraction) coupled with modern analytical technologies (proton transfer reaction mass spectrometry, selected ion flow tube mass spectrometry, ion mobility spectrometry, e-noses, etc.) allow the characterisation of EB composition to an unprecedented level. However, a key challenge in EB analysis is the proper statistical analysis and interpretation of the large and heterogeneous datasets obtained from EB research. There is no standard statistical framework/protocol yet available in literature that can be used for EB data analysis towards discovery of biomarkers for use in a typical clinical setup. Nevertheless, EB analysis has immense potential towards development of biomarkers for the early disease diagnosis of diseases.

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Section: The Metabolics Of Eb Volatilesmentioning

confidence: 99%

Breath Analysis as a Potential and Non-Invasive Frontier in Disease Diagnosis: An Overview

et al. 2015

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“…Methyl ethyl ketone (MEK) is an important industrial solvent that is widely used in paints, varnishes, adhesives, and the refining industry. , In addition, MEK is considered to be a promising fuel because of its good combustion stability and low particulate emissions . It is mainly produced by a two-step process: the hydration of n-butene to produce sec-butanol (SBA) followed by the dehydrogenation of SBA . However, a great amount of hydrogen (H 2 ) is produced as a byproduct of the process of dehydrogenation.…”

Section: Introductionmentioning

confidence: 99%

“…However, a great amount of hydrogen (H 2 ) is produced as a byproduct of the process of dehydrogenation. The byproduct H 2 usually contains a small amount of MEK and SBA, which makes it unsuitable for direct use in the downstream production process. , As a consequence, the byproduct H 2 is sent to a torch for burning, which results in wasted H 2 resources and environmental pollution. In addition, the production of high-quality petrochemicals requires large amounts of H 2 for the hydrogenation process .…”

Section: Introductionmentioning

confidence: 99%

Removal of Methyl Ethyl Ketone and Sec-Butanol from Hydrogen by Absorption with Ionic Liquids

Jiang

Huang

Lei

et al. 2020

Ind. Eng. Chem. Res.

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In this work, a simple and efficient process for capturing methyl ethyl ketone (MEK) and sec-butanol (SBA) simultaneously in hydrogen (H 2 ) gas with ionic liquids (ILs) as absorbents is proposed. Based on a screening of ILs using the COSMO-RS model, the IL [EMIM][Tf 2 N] was chosen as a suitable candidate. The vapor−liquid equilibrium (VLE) for the MEK/SBA + IL system was measured and predicted by the UNIFAC model. Absorption experiments for MEK and SBA with IL were carried out at room temperature and atmospheric pressure. It was found that the IL ([EMIM][Tf 2 N]) exhibits a high absorption capacity for MEK and SBA. Moreover, the highly efficient separation performance is attributed to the formation of hydrogen bonds in the complexes, as explained by excess enthalpy analysis, interaction energy analysis, atoms in molecules topology analysis, electrostatic potential analysis, and independent gradient model analysis.

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“…In this study, we used the retrobiosynthesis framework of BNICE.ch ,,− to explore the biotransformation space around methyl ethyl ketone (MEK). Besides acetone, MEK is the most commercially produced ketone with broad applications as a solvent for paints and adhesives and as a plastic welding agent . MEK shows superior characteristics compared to conventional gasoline and ethanol in terms of its thermophysical properties, increased combustion stability at low engine load, and cold boundary conditions, while decreasing particle emissions .…”

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confidence: 99%

Discovery and Evaluation of Biosynthetic Pathways for the Production of Five Methyl Ethyl Ketone Precursors

et al. 2018

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The limited supply of fossil fuels and the establishment of new environmental policies shifted research in industry and academia toward sustainable production of the second generation of biofuels, with methyl ethyl ketone (MEK) being one promising fuel candidate. MEK is a commercially valuable petrochemical with an extensive application as a solvent. However, as of today, a sustainable and economically viable production of MEK has not yet been achieved despite several attempts of introducing biosynthetic pathways in industrial microorganisms. We used BNICE.ch as a retrobiosynthesis tool to discover all novel pathways around MEK. Out of 1325 identified compounds connecting to MEK with one reaction step, we selected 3-oxopentanoate, but-3-en-2-one, but-1-en-2-olate, butylamine, and 2-hydroxy-2-methylbutanenitrile for further study. We reconstructed 3 679 610 novel biosynthetic pathways toward these 5 compounds. We then embedded these pathways into the genome-scale model of E. coli, and a set of 18 622 were found to be the most biologically feasible ones on the basis of thermodynamics and their yields. For each novel reaction in the viable pathways, we proposed the most similar KEGG reactions, with their gene and protein sequences, as candidates for either a direct experimental implementation or as a basis for enzyme engineering. Through pathway similarity analysis we classified the pathways and identified the enzymes and precursors that were indispensable for the production of the target molecules. These retrobiosynthesis studies demonstrate the potential of BNICE.ch for discovery, systematic evaluation, and analysis of novel pathways in synthetic biology and metabolic engineering studies.

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2‐Butanone

Cited by 13 publications

References 15 publications

Breath Analysis as a Potential and Non-Invasive Frontier in Disease Diagnosis: An Overview

Breath Analysis as a Potential and Non-Invasive Frontier in Disease Diagnosis: An Overview

Removal of Methyl Ethyl Ketone and Sec-Butanol from Hydrogen by Absorption with Ionic Liquids

Discovery and Evaluation of Biosynthetic Pathways for the Production of Five Methyl Ethyl Ketone Precursors

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