2-amino-1,2,3,4-tetrahydropyridines

Chiral phosphoric acid-catalyzed enantioselective construction of structurally diverse benzothiazolopyrimidines

“…Maintained in the chiral cavity by the double hydrogen anchors, rotation of the backbone would furnish a sterically less-congested conformer 8 . Finally the intramolecular nucleophilic addition of benzothiazole to iminium will give the observed cis – trans substituted benzothiazolopyrimidine 4 21. Heating, rapid formation of hydrogen-bonded complex 6 or use of excess 3 may all facilitate the decomplexation of 9 and ensure the catalyst turnover.…”