2-Acetylpyridine thiosemicarbazones. 4. Complexes with transition metals as antimalarial and antileukemic agents

Abstract

Reaction of the 2-acetylpyridine thiosemicarbazones, 3-azabicyclo[3.2.2]nonane-3-thiocarboxylic acid 2-[1-(2-pyridyl)ethylidene]hydrazide (IIIa), its selenium analogue (IIIb), 1H-hexahydroazepine-1-thiocarboxylic acid 2-[1-(2-pyridyl)ethylidene]hydrazide (IV), and 1H-octahydroazocine-1-thiocarboxylic acid 2-[1-(2-pyridyl)ethylidene]hydrazide (V) with Cu(II), Ni(II), Fe(III), and Mn(II) salts gave crystalline complexes. Relative to the free ligands, these complexes show reduced antimalarial activity in mice infected with Plasmodium berghei; however, antileukemic properties are enhanced by coordination with the above-mentioned metals.

Synthesis, Spectral and Biological Properties of Copper (Ii) Complexes of Thiosemicarbazones of Schiff Bases Derived From 4-Aminoantipyrine and Aromatic Aldehydes.

“…This is due to remarkable biological activities observed for these compounds, which has since been shown to be related to their metal complexing ability. These compounds present a great variety of biological activity ranging from antitumour, fungicide, bactereocide, antiinflammatory, and antiviral activities [4][5][6][7][8]. We have previously examined the chelating behaviour of some NNS donor thiosemicarbazones having pyrazolone ring in several metal complexes with the object of gaining more information about their nature of coordination and related structural and spectral properties [9,10].…”

A theoretical investigation on the isomerism and the NMR properties of thiosemicarbazones

“…Transition metal complexes with heterocyclic thiosemicarbazone (TSC) ligands have attracted a great deal of research interest owing to their potential biological activity [1]. TSC ligands have invited considerable interest for a variety of reasons, such as variable bonding properties, because of the presence of several donor sites, structural diversity and pharmacological aspects.…”

Synthesis, Characterisation and Biological Activity of Vanadium (V) With 2,4-Dihydroxy Cinnamaldehyde Thiosemicarbazone (2,4-Dctsc)

“…It is known that some drugs have increased the activity due to the metal complexes 9 . The number of metal chelates inhibits the growth of tumours 10 . In cancer treatments, it has been shown that the active species is not the thiosemicarbazone itself but a metal chelates of the thiosemicarbzones 11 .…”