2. A determination of molecular symmetry in the αβ-diethyl-dibenzyl series

Carlisle, C. H.; Crowfoot, Dorothy

doi:10.1039/jr9410000006

Cited by 31 publications

(11 citation statements)

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“…for C18H20, C, 91-5; H, 8-5%.) This is in agreement with Ramart-Lucas & Anagostopoulos [1928] and also with Kharasch & Kleiman [1943], but not with Rising & Zee [1928] or Carlisle & Crowfoot [1941], who describe it as a crystalline solid.…”

Section: Chemical Methodssupporting

confidence: 90%

The antibacterial action of some stilbene derivatives

Brownlee

Copp

Duffin

et al. 1943

Biochemical Journal

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Early types of antibacterial substances were not specifically antibacterial, but were usually toxic to all living cells, and were of value only in so far as they could be employed without serious damage to the host. The search for more suitable antibacterial agents resulted in the preparation and testing of many substances of widely different constitution, and it was from the empirical yet systematic investigations of one such class of chrysoidine dyestuff that knowledge of the activity of sulphanilamide arose. The growing evidence that the antibacterial action of sulphanilyl drugs was due to competition with an enzymic metabolic process suggested to Fildes [1940] a new approach to the problem. This was the design of antibacterial agents by the synthesis of compounds with a close spatial resemblance to substances vital to, or closely associated with, bacterial growth and reproduction. These growth substances include the water-soluble vitamins of the animal world, which now appear to be essential to the life of all growing cells. The method has been recently used in a sufficiently diverse series of independent investigations to confirm the principle [Mcflwain, 1943]. Other compounds which exert a pronounced physiological activity in minute concentration are the animal hormones related to cyclopentanophenanthrene; for example, oestradiol, when injected into an ovariectomized rat of 50 g. body weight in a dose of 02 jig., is capable of doubling the weight of the uterus; with a blood volume of 2 ml., this represents an activity at a concentration of 1 in 107. These compounds are not known to be hormones for the vegetable kingdom, but they are widely distributed in nature and are probably constituents of all growing cells, being found in all plants and bacteria [Aschheimn & Hohlweg, 1933], as well as in all animals. It seems to us that these compounds can readily be incorporated into the living cell, and that such molecules constitute suitable material

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Section: Chemical Methodssupporting

confidence: 90%

The antibacterial action of some stilbene derivatives

Brownlee

Copp

Duffin

et al. 1943

Biochemical Journal

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“…An extension to more general cases instigated a revolution in determining the structure of crystals of organic substances (72). Extremely complex structures can be elucidated by this method and the related isomorphous replacement technique.…”

Section: Structure In Three Dimensionsmentioning

confidence: 99%

Origins of Molecular Biology

Hess

1970

Science

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“…A. Bond Lengths The crystal and molecular structures of six steroids have been determined by x-ray crystallographic techniques (1)(2)(3)(4)(5)(6) (Fig. 1).…”

Section: Presentation Of Steroid Structural Datamentioning

confidence: 99%

Preparation of Steroid Structural Data for the Consideration of Possible Structural-Functional Relationships

Norton¹

1965

Biophysical Journal

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A format has been established for the presentation of steroid structural data which may prove to be useful in the consideration of the possible structural-functional relationships of steroids in biological systems. In preparing this format the detailed structural information for all steroids with known crystallographic structures has been computed and summarized, including bond lengths and angles, non-planarity coefficients, dihedral angles, length of the steroid nucleus, and side group inclinations. From the structural point of view it is interesting to note that (a) bond lengths do not differ significantly from the theoretical values, (b) bond angles do differ significantly from the theoretical values, (c) the non-planarity coefficient of the steroid molecule seems to be a function of the number of angular methyl groups but is unaffected by the presence of one heavy atom, (d) except where aromatic bonds are present the non-planarity coefficients of the two-ring and one-ring subdivisions of the steroid nucleus is 0.25 A, (e) the average non-planarity coefficient of the ring joins and "seat" portions of the chairs is 0.03 A, (f) dihedral angles deviate from the theoretically expected values and also show wide variation in the steroids studied, (g) the length of the steroid nucleus is variable, (h) analysis of side group inclination data must be deferred until more steroid structural information is available. From the biological point of view it is currently impossible to estimate the importance of each steroid structural feature in determining physiological function.

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2. A determination of molecular symmetry in the αβ-diethyl-dibenzyl series

Cited by 31 publications

References 0 publications

The antibacterial action of some stilbene derivatives

The antibacterial action of some stilbene derivatives

Origins of Molecular Biology

Preparation of Steroid Structural Data for the Consideration of Possible Structural-Functional Relationships

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