2.62 Dasotraline in Children With ADHD: Effects on Sleep Habits as Measured by the Children’s Sleep Habits Questionnaire

Association between sleep pattern and pharmacological treatment in children with attention deficit disorder with hyperactivity: a systematic review

“…Additional information about the studies is provided in Table 1. [10][11][12][13][14][15][16][17][18][19][20] For intervention, the most commonly used drug was methylphenidate (MPH) (n=1,394), followed by atomoxetine (ATX) (n=358). Other drugs used were guanfaxine (n=29), dasotraline (n=342), l-theanine (n=93), and lisdexamfetamine (LDX) (n=24).…”

“…Figure 2 shows the characteristics of the included studies and their risk of bias, and Figure 3 [10][11][12][13][14][15][16][17][18][19][20] shows the risk of bias summary: review authors' judgments on each risk of bias item in the included studies. For randomized clinical trials, the following five risks of bias domains were considered:…”

“…The use of dasotraline evaluated by Goldman et al 18 culminated in the identification of insomnia as an adverse event more commonly in the group that received the drug compared to patients treated with placebo. In this regard, it has already been used in the clinical trial by Findling et al, 25 who also pointed to insomnia as one of the main adverse effects.…”

“…In short, MPH in the treatment of ADHD in children can contribute to interpersonal relationships, increase concentration, and decrease aggression, although side effects are found, including the repercussions on sleep mentioned by the studies presented above. 24 The use of dasotraline evaluated by Goldman et al 18 culminated in the identification of insomnia as an adverse event more commonly in the group that received the drug compared to patients treated with placebo. In this regard, it has already been used in the clinical trial by Findling et al, 25 who also pointed to insomnia as one of the main adverse effects.…”