Abstract:Abstract2,6‐diaminopurine (Z), a naturally occurring noncanonical nucleotide base found in bacteriophages, enhances DNA hybridization by forming three hydrogen bonds with thymine (T). These distinct biochemical characteristics make it particularly valuable in applications that rely on the thermodynamics of DNA hybridization. However, the practical use of Z‐containing oligos is limited by their high production cost and the challenges associated with their synthesis. Here, we developed an efficient and cost‐effe… Show more
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