2,500 Living Donor Kidney Transplants: A Single-Center Experience

Abstract

ObjectiveTo review a single center's experience and outcome with living donor transplants. Summary Background DataOutcome after living donor transplants is better than after cadaver donor transplants. Since the inception of the authors' program, they have performed 2,540 living donor transplants. For the most recent cohort of recipients, improvements in patient care and immunosuppressive protocols have improved outcome. In this review, the authors analyzed outcome in relation to protocol. MethodsThe authors studied patient and graft survival by decade. For those transplanted in the 1990s, the impact of immunosuppressive protocol, donor source, diabetes, and preemptive transplantation was analyzed. The incidence of rejection, posttransplant steroid-related complications, and return to work was determined. Finally, multivariate analysis was used to study risk factors for worse 1-year graft survival and, for those with graft function at 1 year, to study risk factors for worse long-term survival. ResultsFor each decade since 1960, outcome has improved after living donor transplants. Compared with patients transplanted in the 1960s, those transplanted in the 1990s have better 8-year actuarial patient and graft survival rates. Death with function and chronic rejection have continued to be a major cause of graft loss, whereas acute rejection has become a rare cause of graft loss. Cardiovascular deaths have become a more predominant cause of patient death; infection has decreased. Donor source (e.g., ideally HLA-identical sibling) continues to be important. For living donor transplants, rejection and graft survival rates are related to donor source. The authors show that patients who had preemptive transplants or less than 1 year of dialysis have better 5-year graft survival and more frequently return to full-time employment. Readmission and complications remain problems; of patients transplanted in the 1990s, only 36% never required readmission. Similarly, steroid-related complications remain common. The authors' multivariate analysis shows that the major risk factor for worse 1-year graft survival was delayed graft function. For recipients with 1-year graft survival, risk factors for worse long-term outcome were pretransplant smoking, pretransplant peripheral vascular disease, pretransplant dialysis for more than 1 year, one or more acute rejection episodes, and donor age older than 55. ConclusionsThese data show that the outcome of living donor transplants has continued to improve. However, for living donors, donor source affects outcome. The authors also identify other major risk factors affecting both short-and long-term outcome.The first successful kidney transplants in humans were from identical twin living donors.1,2 Although transplanted before the development of chemical immunosuppression, many of these identical twin grafts had long-term survival. With recognition of the immunosuppressive effects of prednisone and azathioprine, the use of nontwin donors became possible.3,4 Considerable controversy soon follow...

Smoking

“…Other studies have also found a negative effect of smoking (43)(44)(45). Of the 279 patients who were investigated in an Austrian study (45), smokers had higher serum creatinine values (2.3 Ϯ 2.7 versus 1.8 Ϯ 1.4 mg/dl; P ϭ 0.21) and tended to develop transplant failure (33.3 versus 21.2%; P ϭ 0.25).…”

Psuedo-aneurysm following Renal Transplantation Presenting as Extensive Ileofemoral Thrombosis

“…Medical or surgical complications can occur following renal transplant in up to 10% of patients [3,4]. Surgical complications usually encountered include ureteral problems (obstruction, urinoma, or lymphocele) or vascular problems (stenosis or thrombosis of renal artery, arterio venous fistula, thrombosis of renal vein or iliac vein, bleeding, perigraft hematoma or pseudo aneurysm).…”

Biomarkers for renal transplantation: where are we?

“…To some extent, the quality of donor organs determines transplant outcome. 12 It is well known that living donor organs function better than those from deceased donors. Accordingly, the biomarkers for kidney transplantation can be divided into two types: biomarkers for living donors, and biomarkers for deceased donors.…”