2'-5' Oligo(A) Synthetase Levels in Interferon-sensitive or -resistant Lymphoid Cells

Koliais, S. I.; Kortsaris, A.

doi:10.1099/0022-1317-58-1-191

Cited by 9 publications

(3 citation statements)

References 16 publications

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“…As in many interferon-treated cell systems, the enzyme 2',5'-oligo(A) synthetase is induced in Daudi cells within 8-12 h [6,28]. Fig.1 illustrates the time course of induction and shows that no further increase in enzyme activity is observed after 24 h. The level of the enzyme thus does not cor- fig.2.…”

Section: Resultsmentioning

confidence: 93%

Regulation of protein synthesis in lymphoblastoid cells during inhibition of cell proliferation by human inteferons

et al. 1984

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Treatment of human lymphoblastoid (Daudi) cells with interferons inhibits cell proliferation in culture within 24 h. The failure of cell growth has been shown to be associated with impaired processing and decreased stability of newly replicated DNA. Because there is a close relationship between DNA replication and protein synthesis we have measured protein synthesis in intact Daudi cells. Protein synthesis declined steadily between 24 and 96 h after interferon treatment to a value which is only 20–30% of the rate in control cells. The enzyme 2′,5′‐oligo(A) synthetase is induced but our data do not support a role for the 2′,5′‐oligo(A)‐activated ribonuclease in the control of translation in this system.

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Section: Resultsmentioning

confidence: 93%

Regulation of protein synthesis in lymphoblastoid cells during inhibition of cell proliferation by human inteferons

et al. 1984

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“…The activity of 2',5' oligo(A) synthetase is estimated by following the conversion of 3H-labelled ATP (Amersham) to adenosine oligomers as in [9]. Incubations were for 24 h at 30°C followed by precipitation of the mixture with 6~01s acetone.…”

Section: Assay Of2'5' Andgo(a) Synthetasementioning

confidence: 99%

Induction of 2′,5′ oligo(A) synthetase in tumor‐bearing mice with encephalomyocarditis (EMC) virus of poly(I)poly(C)

1983

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Infection of 13 month‐old C3H mice with EMC virus or inoculation with the interferon inducer poly(I)poly(C) results in elevated levels of the enzyme 2′,5′ oligo(A) synthetase only in animals with spontaneous tumors (breast cancer or hepatomas). High enzymatic activities are detected in homogenates from liver, spleen, plasma and neoplastic cells of the animals with breast carcinomas and only in the neoplastic liver cells of the animals with hepatomas.

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“…Πάντως δεν είναι ακόμα γνωστό αν τα νεοπλασματικά κύτταρα είναι πιο ευαί σθητα στην ιντερφερόνη από τα κανονικά. Εξ άλλου, η ευαισθησία των δια φόρων κυττάρων στις αντικυτταρικές ιδιότητες της ιντερφερόνης ποικίλ λει πολύ(31). γ) Η ιντερφερόνη μπορεί να προκαλέσει μεταβολές και στην κυτταρική επιφάνεια, π.χ.…”

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Μελετες Πανω Στις Αντι-Ιικες Και Αντικυτταρικες Ιδιοτητες Της Ιντερφερονης

Λαμπρόπουλος¹,

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2'-5' Oligo(A) Synthetase Levels in Interferon-sensitive or -resistant Lymphoid Cells

Cited by 9 publications

References 16 publications

Regulation of protein synthesis in lymphoblastoid cells during inhibition of cell proliferation by human inteferons

Regulation of protein synthesis in lymphoblastoid cells during inhibition of cell proliferation by human inteferons

Induction of 2′,5′ oligo(A) synthetase in tumor‐bearing mice with encephalomyocarditis (EMC) virus of poly(I)poly(C)

Μελετες Πανω Στις Αντι-Ιικες Και Αντικυτταρικες Ιδιοτητες Της Ιντερφερονης

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