Abstract:Background-We previously reported that 2,5-dimethylcelecoxib (DMC) activated glycogen synthase kinase-3 (GSK -3), a negative regulator of cardiac hypertrophy, in mice. In this study, we examined the effects of DMC on isoprenaline (ISO)-induced cardiac hypertrophy and fibrosis using in vivo and in vitro systems.Methods-ISO (20 mg/kg/day) was administered to C57BL/6J mice using an osmotic pump, and DMC (1,000 ppm) was added into feed for 14 days. Mice were divided into 3 groups: Control, ISO and ISO+DMC. Primary… Show more
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