“…[10] Thereafter, a number of ligands have been applied to promote the catalytic activity of copper salts for Sonogashira coupling. [8,9] Both phosphine [11][12][13] and non-phosphine ligands, such as phenanthroline, [14] DABCO, [15] β-diketone, [16] 8hydoxyquinoline, [17] rac-BINOL, [18] N,N'-dibenzyl-BINAM, [19] salicyclic acid, [20] (À )-sparteine, [21] TMEDA, [22] ethylene glycol, [23,24] pyrene [25] and DMEDA [26] are reported for this Csp 2 À Csp crosscoupling reaction using copper catalysts. Joshaghani used a combination of Ni(acac) 2 and CuI in presence of 2,6bis(diphenylphosphino)pyridine as ligand for palladium-free Sonogashira cross-coupling reaction.…”