2-(4-Fluorophenyl)-1H-benzo[d]imidazole as a Promising Template for the Development of Metabolically Robust, α1β2γ2GABA-A Receptor-Positive Allosteric Modulators
Abstract:Modulation of α1β2γ2GABA-A receptor
subpopulation
expressed in the basal ganglia region is a conceptually novel mode
of pharmacological strategy that offers prospects to tackle a variety
of neurological dysfunction. Although clinical findings provided compelling
evidence for the validity of this strategy, the current chemical space
of molecules able to modulate the α1/γ2 interface of the
GABA-A receptor is limited to imidazo[1,2-a]pyridine
derivatives that undergo rapid biotransformation. In response to a
defi… Show more
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