2-(4′-chlorophenyl)-1,4-benzoquinone increases the frequency of micronuclei and shortens telomeres

Jacobus, James A.; Flor, Susanne; Klingelhutz, Aloysius J.; Robertson, Larry W.; Ludewig, Gabriele

doi:10.1016/j.etap.2007.10.022

Cited by 31 publications

(43 citation statements)

References 22 publications

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“…Our results are inconsistent with the findings of prior in vitro studies that observed telomere shortening because of exposure to PCB 153, PCB 126, PCB 52, PCB 28, or 2-(4′-chlorophenyl)-1, 4-benzoquinone (PCB3pQ) (Jacobus et al, 2008; Senthilkumar et al, 2011; Senthilkumar et al, 2012; Xin et al, 2016; Ziegler et al, 2016). Alternative mechanisms by which PCBs may induce telomere lengthening have been proposed (Scinicariello and Buser, 2015).…”

Section: Discussioncontrasting

confidence: 99%

“…In vitro , immortalized human skin keratinocytes, hamster lung fibroblasts, immortalized lymphocytes, or human promyelocytic leukemia cells exposed to PCB 153, PCB 126, PCB 52, PCB 28, or 2-(4′-chlorophenyl)-1, 4-benzoquinone (PCB3pQ), have shortened telomeres (Jacobus et al, 2008; Senthilkumar et al, 2011; Senthilkumar et al, 2012; Xin et al, 2016; Ziegler et al, 2016). Conversely, PCB 138 and PCB 153 upregulate c- myc in vitro (Ghosh et al, 2007; Gribaldo et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Serum polychlorinated biphenyls and leukocyte telomere length in a highly-exposed population: The Anniston Community Health Survey

Callahan

Pavúk

Birnbaum

et al. 2017

Environment International

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Background Serum polychlorinated biphenyls (PCBs) have previously been associated with longer leukocyte telomere length (LTL) in most, but not all, of the few previous studies. PCBs were produced in Anniston, Alabama from 1929–1971 and participants of the Anniston Community Health Survey (ACHS) were highly exposed. Objectives We evaluated serum levels of 35 PCBs and relative telomere length in 559 ACHS participants. Methods Relative LTL was measured in DNA extracted from blood clots. We assessed PCBs individually, grouped by chlorination, and summed PCBs. We used linear regression to assess the association between each PCB metric while adjusting for pertinent covariates. Results Serum PCBs were associated with longer LTL among white participants and the oldest age group of black participants. Among white participants, compared with those in the first quartile of sum PCBs those in the third quartile of sum PCBs had 8.09% longer relative LTL (95% CI: 1.99; 14.55) and those in the fourth had 7.58% longer relative LTL (95%CI: −0.01; 15.76) (p-quadratic = 0.05). Among African American participants, serum PCBs were associated with longer relative LTL among those over age 64 only. Tests for interaction were not statistically significant. Conclusions We observed a non-linear positive association between serum PCBs and LTL among white participants. Serum PCBs were associated with longer LTL in the oldest age group of African Americans. This association may provide insight into the cancers previously associated with exposure to PCBs, melanoma and non-Hodgkin lymphoma, which have been associated with long LTL in previous studies.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum polychlorinated biphenyls and leukocyte telomere length in a highly-exposed population: The Anniston Community Health Survey

Callahan

Pavúk

Birnbaum

et al. 2017

Environment International

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“…This finding is probably due to the influence of exposure on genes involved in the telomere length maintenance (32). Correlation of age and telomere length in our study suggested a possible influence of the widespread environmental and occupational ha zards ex posure on ageing acceleration (33)(34)(35), through shortening the telomere length.…”

Section: Discussionmentioning

confidence: 59%

Association Between Telomere Shortening and Ageing During Occupational Exposure

Eshkoor¹,

Jahanshiri²,

Ismail³

et al. 2012

Journal of Medical Biochemistry

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Summary: Telomere length is considered as a biomarker of ageing, resulting in shortening during the process. The present investigation was an attempt to determine the relative telomere length in mechanical workshop workers. Telomere length shortening in cells during occupational expo sure causes accelerated ageing. Genomic DNA was isolated from buccal epithelial cells collected from 240 individuals, comprising two groups of 120 exposed workers and 120 unexposed controls. Telomere length was measured by using real time PCR. Both telomere (T) and single copy gene (S) specific primers were used to compute the relative T/S ratio and expressed as the relative telomere length. Telomere length differed significantly between the workers and controls (p<0.05). The results showed an indirect and significant association (r=-0.356, p=0.001) between age and telomere length in the workers. This study showed that the difference in telomere length shortening was statistically significant (p<0.05) between the workers and controls. It was concluded that occupational exposure acts as a risk factor to enhance telomere length shortening and accelerate ageing.Keywords: telomere, 36B4 gene, ageing, occupational exposure, buccal cells, real-time PCR Kratak sadr`aj: Du`ina telomera smatra se biomarkerom starenja i tokom ovog procesa rezultira skra}enjem. Ovo istra`ivanje predstavlja poku{aj odre|ivanja relativne du`ine telomera kod radnika u mehani~arskim radionicama. Skra}enje du`ine telomera u }elijama tokom profesionalne izloenosti izaziva ubrzano starenje. Genomska DNK izolovana je iz epitelnih }elija unutra{nje strane obraza sakupljenih od 240 osoba, koji su ~inili dve grupe: 120 profesionalno izloenih radnika i 120 neizlo`enih kontrolnih subjekata. Du`ina telomera izmerena je tehnikom PCR u realnom vremenu. Specifi~ni prajmeri telomera (T) i gena prisutnih u jednoj kopiji (S) upotrebljeni su za izra~unavanje relativne razmere T/S i izra`eni kao relativna du`ina telomera. Du`ina telomera zna~ajno se razlikovala izme|u radnika i kontrolnih subjekata (p<0,05). Rezultati su pokazali da izme|u starosti i du`ine telomera kod radnika postoji indirektna i zna~ajna pove zanost (r=-0,356, p=0,001). Ova studija je pokazala da je razlika u skra}enju du`ine telomera izme|u radnika i kontrolnih subjekata bila statisti~ki zna~ajna (p<0,05). Zaklju~eno je da profesionalna izlo`enost predstavlja faktor rizika za znatnije skra}enje du`ine telomera i ubrzano starenje.Klju~ne re~i: telomera, gen 36B4, starenje, profesionalna izlo`enost, }elije unutra{nje strane obraza, PCR u realnom vremenu

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“…Previous studies have reported that chronic dietary administration of BHA caused DNA damage [3] and even induced papilloma and carcinoma formation in forestomach of rats, mice and hamsters [4,5]. Moreover, BHA has been shown to act as a tumor initiator or promoter in a variety of tissues and organs, and its quinone-forming metabolites which are highly reactive molecules with binding to biological macromolecules [6] can also induce chromosomal loss or chromosomal breakage [7]. Because of the widespread uses of BHA, it is necessary to critically evaluate the safety of this antioxidant.…”

Section: Introductionmentioning

confidence: 99%

Intercalation binding of food antioxidant butylated hydroxyanisole to calf thymus DNA

Wang

Zhang

Pan

et al. 2014

Journal of Photochemistry and Photobiology B: Biology

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2-(4′-chlorophenyl)-1,4-benzoquinone increases the frequency of micronuclei and shortens telomeres

Cited by 31 publications

References 22 publications

Serum polychlorinated biphenyls and leukocyte telomere length in a highly-exposed population: The Anniston Community Health Survey

Serum polychlorinated biphenyls and leukocyte telomere length in a highly-exposed population: The Anniston Community Health Survey

Association Between Telomere Shortening and Ageing During Occupational Exposure

Intercalation binding of food antioxidant butylated hydroxyanisole to calf thymus DNA

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