2, 4, 6-Trithiol-1, 3, 5-Triazine-Modified Gold Nanoparticles and Its Potential as Formalin Detector

Yulizar, Yoki; Ariyanta, Harits Atika; Rakhmania, L.; Hafizah, Mas Ayu Elita

doi:10.1088/1757-899x/349/1/012072

Cited by 3 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gold nanoparticles (AuNPs) led to the development of a new kind of nanomaterials, taking advantage of their optical properties and high physical stability that make them a very viable option for several applications [21–25]; hereby, they present improvements for cellular transfection over lipocomplexes or polymers, by having higher density and so reducing uptake time [12]. As gold has a great affinity to amino (-NH 2 ), cyano (-CN), and thiol (-SH) functional groups, vast opportunities are open for many types of functionalization [9, 26]. Cationic monolayers are obtained, for instance, by adding cationic polymers to gold nanoparticles, improving nucleic acid interaction and electrostatic adsorption [27, 28].…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles with chitosan, N-acylated chitosan, and chitosan oligosaccharide as DNA carriers

et al. 2019

View full text Add to dashboard Cite

Currently, gold nanoparticles have found applications in engineering and medical sciences, taking advantage from their properties and characteristics. Surface plasmon resonance, for instance, is one of the main features for optical applications and other physical properties, like high density, that represents the key for cellular uptake. Among other applications, in the medical field, some diseases may be treated by using gene therapy, including monogenetic or polygenetic disorders and infections. Gene adding, suppression, or substitution is one of the many options for genetic manipulation. This work explores an alternative non-viral method for gene transfer by using gold nanoparticles functionalized with organic polymers; two routes of synthesis were used: one of them with sodium borohydride as reducing agent and the other one with chitosan oligosaccharide as reducing and stabilizing agent. Gold nanoparticles conjugated with chitosan, acylated chitosan and chitosan oligosaccharide, were used to evaluate transfection efficiency of plasmid DNA into cell culture (HEK-293). Physical and chemical properties of gold nanocomposites were characterized by using UV-Vis Spectroscopy, ξ - potential, and transmission electron microscopy. Furthermore, the interaction between gold nanoparticles and plasmid DNA was demonstrated by using agarose gel electrophoresis. Transfection tests were performed and evaluated by β-galactosidase activity and green fluorescence protein expression. The percentage of transfection obtained with chitosan, acylated chitosan, and chitosan oligosaccharide were of 27%, 33%, and 60% respectively.

show abstract

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles with chitosan, N-acylated chitosan, and chitosan oligosaccharide as DNA carriers

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The toxicity of gold nanoparticles depends on the particle size, shape, chemical composition, surface charge, and dose(Hornos Carneiro & Barbosa, 2016). Gold nanoparticles are one of the most exciting nanomaterials in various applications because of their stable physical and optical properties(Abrica-González et al, 2019; Yulizar et al, 2018). Gold nanoparticles are synthesized using various methods (Herizchi et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Evaluation and In vitro Study of Lung Cancer Cell therapeutic Target using Chitosan- Gold Nanoparticles Loaded Lapatinib

Rezaeiaghdam,

Peymani,

Akbarzadeh

et al. 2023

Preprint

View full text Add to dashboard Cite

Purpose Long non-coding ribonucleic acids (lncRNAs) play a crucial role in cancer progression by affecting cell proliferation, apoptosis, and metastasis. Targeting lncRNAs with chemotherapy drugs and overcoming drug resistance pose significant challenges. This study aimed to identify candidate oncogenic lncRNAs in lung cancer through transcriptome analysis and propose a drug targeting these lncRNAs. Methods Using data from the Cancer Genome Atlas (TCGA) database, lncRNAs with significantly increased expression in lung adenocarcinoma and lung squamous cell carcinoma were identified (FDR < 0.01, log fold change >). The relationship between lncRNA expression and patient survival was assessed using Cox regression analysis. Furthermore, lncRNAs associated with other common cancers were selected. The GEO profile database was utilized to identify drugs that had a substantial impact on the expression of the identified lncRNAs. Chitosan gold nanoparticles were employed to demonstrate the efficacy of the selected drug, and in vitro experiments were conducted using A549 cells to evaluate cytotoxicity, apoptosis induction, and changes in lncRNA expression levels. Results The expression level of LINC01615 was found to be increased in lung cancer and several other cancers and was associated with poor prognosis in lung cancer patients. Lapatinib was identified as an effective drug to control the expression of LINC01615 in multiple cancers. In vitro studies using Lapatinib-chitosan-gold nanoparticles demonstrated reduced cell viability and induction of apoptosis in A549 cells, along with decreased expression of LINC01615. Conclusion LINC01615 holds potential as a predictive biomarker for survival in breast, kidney, liver, and lung cancer patients. Lapatinib-chitosan-gold nanoparticles offer an effective approach for controlling LINC01615 expression and cell viability in lung cancer.

show abstract

Label-Free Immunosensing of Telomerase Using Bio-Conjugation of Biotinylated Antibody to Poly(Chitosan) Gold Nanoparticles

2023

View full text Add to dashboard Cite

Aim: This study aimed to establish a label-free electrochemical biosensor for telomerase detection in human biofluid. Method: Synthesized green nanocomposite (poly[chitosan] decorated by gold nanoparticles) was used for the efficient immobilization of biotinylated antibody of telomerase and immunocomplex of antigen-antibody. Poly(chitosan) was decorated by gold nanoparticles on the surface of a glassy carbon electrode using an electrochemical coating technique. Results: The constructed immunosensor exhibited wide dynamic range (0.078–160 IU/ml-1) with a low limit of quantification of 0.078 IU/ml-1, which present a unique manner for telomerase assays in early prognosis for cancers. Conclusion: This study encourages scientists and scholars to design and develop new biosensor platforms for point-of-care diagnostics for telomerase management, an interesting reference for future research.

show abstract

2, 4, 6-Trithiol-1, 3, 5-Triazine-Modified Gold Nanoparticles and Its Potential as Formalin Detector

Cited by 3 publications

References 31 publications

Gold nanoparticles with chitosan, N-acylated chitosan, and chitosan oligosaccharide as DNA carriers

Gold nanoparticles with chitosan, N-acylated chitosan, and chitosan oligosaccharide as DNA carriers

Evaluation and In vitro Study of Lung Cancer Cell therapeutic Target using Chitosan- Gold Nanoparticles Loaded Lapatinib

Label-Free Immunosensing of Telomerase Using Bio-Conjugation of Biotinylated Antibody to Poly(Chitosan) Gold Nanoparticles

Contact Info

Product

Resources

About