2,4,6-Triphenylpyrylium Tetrafluoroborate

Balaban, Alexandrù T.

doi:10.1002/047084289x.rt384

Cited by 3 publications

(3 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…28 In contrast, treatment of triphenylpyrylium salt 9 under similar conditions is not efficient due to undesired formation of 7-membered ring 10 with an endocyclic N-N bond (Scheme 6b). 29 To overcome this challenge, a two-step protocol was employed based on initial reaction of pyrylium salt 9 with 2-aminopyridine to afford pyridinium salt 11 followed by subsequent hydrazinolysis to form the desired N-aminopyridinium salt 12 (Scheme 6c). 30 Condensation of unsubstituted pyrylium salts with simple hydrazine has not been reported to our knowledge, however, Studer et al reported the reaction of unsubstituted pyrylium salt 13 with N-aminophthalimide 14 to afford N-aminopyridinium salt 15 (Scheme 6d).…”

Section: From Hydrazinesmentioning

confidence: 99%

N-Amino pyridinium salts in organic synthesis

et al. 2023

View full text Add to dashboard Cite

show abstract

Section: From Hydrazinesmentioning

confidence: 99%

N-Amino pyridinium salts in organic synthesis

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Despite the inherent instability of oxonium ions, pyrylium salts exhibit aromatic stability, resulting in their formation. [1,2] . These salts show high reactivity towards nucleophiles and hence act as a nodal point for the synthesis of various organic molecules.…”

Section: Introductionmentioning

confidence: 99%

“…benzopyrylium salts, 7 being novel, were synthesized by Claisen-Schmidt condensation reaction and characterized by1 H and13 C NMR, High-Resolution Mass Spectrometry, FT-IR and UV-Vis spectroscopy. The purity of these synthesized compounds was determined by HPLC.…”

mentioning

confidence: 99%

Synthesis, Characterization, In‐Vitro and In‐Vivo Anti‐Cancer Evaluation of Novel Benzopyrylium Salts on Colorectal Cancer Model of Drosophila Melanogaster

Rai,

Kumar,

Singh

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

A total of 10 benzopyrylium salts, 7 being novel, were synthesized by Claisen‐Schmidt condensation reaction and characterized by 1H and 13C NMR, High‐Resolution Mass Spectrometry, FT‐IR, and UV‐Vis spectroscopy. The purity of these synthesized compounds was determined by HPLC. The in‐vitro anti‐cancer evaluation of these synthesized benzopyrylium salts was done at National Cancer Institute (NCI), USA, against 60 human cancer cell lines. The compounds 4 and 8 showed promising anti‐cancer activities against various human cancer cell lines. The docking studies of the compounds were carried out against the oncogenic target JNK and their docking scores were compared to that of the known JNK inhibitor SP600125 (Pyrazolanthrone). Compound 4 exhibited an outstanding docking score of −9.0 kcal/mol, comparable to the docking score of SP600125 (−9.3 kcal/mol). The ex‐vivo studies in the hind‐gut of Drosophila were carried out and the inhibitory activity of compound 4 supported the findings of the docking studies. Furthermore, the potent compounds 4 and 8 were taken up for their in‐vivo anti‐cancer evaluation in the colorectal cancer model (CRC) of Drosophila melanogaster. The toxicity studies of these potent compounds were carried out both in wild type and mutant type Drosophila and the lethal doses were determined to be 200 μM.

show abstract