2,3-Disubtituted Thiazolidin-4-ones: Novel Class of Anticonvulsant Agents

Senthilraja, M.; Alagarsamy, V.; Solomon, V. Raja

doi:10.2174/157018012801319517

Cited by 3 publications

(2 citation statements)

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“…Thiazolidinone is one of the most frequent heterocyclic nucleuses as it exhibits many types of biological activities [1]. It has been reported that thiazolidin-4-ones are explored as anti-inflammatory [2][3][4][5], antiviral [6,7], anticonvulsant [8][9][10], antidiabetic [11], anticancer [12] and anti-HIV [13][14][15] activities. Also, the thiazolidin-4-one ring occurs in nature, for example, actithiazic acid [(-)-2-(5-carboxyphenyl)thiazolidin-4-one)] was isolated from Streptomyces [16].…”

Section: Introductionmentioning

confidence: 99%

Stereoselective synthesis of 2-(2,4-dinitrophenyl)hydrazono- and (2-tosylhydrazono)-4-oxo-thiazolidine derivatives and screening of their anticancer activity

et al. 2020

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Stereoselective synthesis of (Z)-methyl 2-[(Z)-3-substituted-2-(2-(2,4-dinitrophenyl)hydrazono)-4-oxothiazolidine-5-ylidine)]acetates and (Z)-methyl 2-[(Z)-3-substituted-2-(2-(tosylhydrazono)-4-oxothiazolidine-5ylidine)]acetates via the cyclization of N-substituted-2-arylhydrazinocarbothioamides with dialkyl acetylenedicarboxylates in absolute ethanol is reported. The structures were confirmed by spectroscopic data as well as single crystal X-ray analyses. The mechanism of nucleophilic addition and the role of electronic factors were discussed. The anticancer activity of the newly synthesized compounds was evaluated against a panel of 60 cell lines derived from nine different types of cancers including, leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and breast cancers and the results revealed that the cyclohexyl derivative has a significant broad anticancer activity especially against different leukemia and colon cancer cell lines . MCCM_Template_Vers 4

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Section: Introductionmentioning

confidence: 99%

Stereoselective synthesis of 2-(2,4-dinitrophenyl)hydrazono- and (2-tosylhydrazono)-4-oxo-thiazolidine derivatives and screening of their anticancer activity

et al. 2020

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“…Even though the many antibiotics, drugs and chemotherapeutic available, the emergence of old and newer antibiotic-resistant bacterial strains in the last two decades created an urgent need for the discovery and development of new antimicrobials with a broader spectrum of activity and lower toxicity. [1][2][3] The 2-thioxothiazolidin-4-one (Rhodanine) based molecules exhibit biological activities, such as antidiabetic, 4 anticancer, 5 antitubercular, 6,7 anti-HIV, [8][9][10] antiparasitic, 11 anticonvulsant, 12 and antiproliferative. 13,14 Thiazole also has anti-inflammatory, 15 anticancer, 16 anti-fungal 17 and antimicrobial 18 activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 2-((5-Benzylidene-4-Oxo-4,5-Dihydrothiazol-2-Yl)-Substituted Amino Acids as Anticancer and Antimicrobial Agents

Shelke¹,

Pansare²,

Pawar³

et al. 2019

ECB

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A series of Rhodanine derivatives were synthesized by Knoevenagel condensation. All the synthesized compounds were tested for their in vitro anticancer activity against MCF-7 and BT-474 human breast cancer cell lines. All the synthesized compounds were characterized and screened for their antimicrobial activity against the bacterial and fungal strain. Majority of the compounds showed good to moderate anticancer and antimicrobial activity. Among these compounds, one showed promising activity against gram-positive bacteria B. subtilis and S. aureus when compared with ampicillin. Some of the most potent compounds possessed selective antimicrobial activity.

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Synthesis of thiazolidines via regioselective addition of unsymmetric thioureas to maleic acid derivatives

et al. 2014

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2,3-Disubtituted Thiazolidin-4-ones: Novel Class of Anticonvulsant Agents

Cited by 3 publications

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Stereoselective synthesis of 2-(2,4-dinitrophenyl)hydrazono- and (2-tosylhydrazono)-4-oxo-thiazolidine derivatives and screening of their anticancer activity

Stereoselective synthesis of 2-(2,4-dinitrophenyl)hydrazono- and (2-tosylhydrazono)-4-oxo-thiazolidine derivatives and screening of their anticancer activity

Synthesis of 2-((5-Benzylidene-4-Oxo-4,5-Dihydrothiazol-2-Yl)-Substituted Amino Acids as Anticancer and Antimicrobial Agents

Synthesis of thiazolidines via regioselective addition of unsymmetric thioureas to maleic acid derivatives

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