2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: Synthesis and Biological evaluation as potential antiproliferative and antifungal agents

Tandon, Vishnu K.; Maurya, Hardesh K.; Tripathi, Ashutosh; ShivaKeshava, G.B.; Shukla, Praveen Kumar; Srivastava, Pallavi; Panda, Dulal

doi:10.1016/j.ejmech.2008.06.025

Cited by 98 publications

(43 citation statements)

References 33 publications

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“…These compounds and pentacyclic phenothiazine (modified with the naphthalene and naphthoquinone rings) 17 showed weak antifungal activity against 6 fungi with MIC 50 50 mg/ml. These compounds exhibited better anticancer activity (see below) [31].…”

Section: Antibacterial and Antifungal Activitiesmentioning

confidence: 99%

Recent progress in biological activities of synthesized phenothiazines

Pluta¹,

Morak‐Młodawska²,

Jeleń³

2011

European Journal of Medicinal Chemistry

260

122

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Section: Antibacterial and Antifungal Activitiesmentioning

confidence: 99%

Recent progress in biological activities of synthesized phenothiazines

Pluta¹,

Morak‐Młodawska²,

Jeleń³

2011

European Journal of Medicinal Chemistry

260

122

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“…Naphthoquinones and their various derivatives as a class display many types of biological activity. They are active against different strains of bacteria and fungi [1][2][3][4][5][6][7][8][9][10], show insecticidal [11,12], molluscicidal [13], and antiproliferative [4,14] properties, and are anticancer agents [15][16][17][18][19][20]. Furthermore, hydrazones have been demonstrated to possess many types of biological activity [21].…”

Section: Introductionmentioning

confidence: 99%

Reactions of 5-oxo-1-phenylpyrrolidine-3-carbohydrazides with 1,4-naphthoquinone derivatives and the properties of the obtained products

et al. 2011

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N 0 -(4-Oxo-1,4-dihydronaphthalen-1-ylidene)-1-phenyl-5-oxopyrrolidine-3-carbohydrazides and N 0 -(3-methyl-4-oxo-1,4-dihydronaphthalen-1-ylidene)-1-phenyl-5-oxopyrrolidine-3-carbohydrazides were synthesized by reactions of 5-oxo-1-phenylpyrrolidine-3-carbohydrazides with 1,4-naphthoquinone or 2-methyl-1,4-naphthoquinone. The alkylated analogues of the above products were obtained using ethyl iodide. The interaction of 5-oxo-1-phenylpyrrolidine-3-carbohydrazides with 2,3-dichloro-1,4-naphthoquinone was followed by formation of N 0 -(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-1-phenyl-5-oxopyrrolidine-3-carbohydrazides. All these compounds were characterized using 1 H, 13 C NMR, IR and mass spectra. Some of the new compounds were tested for the antimicrobial and antifungal activity.

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“…Phenothiazine occurs in various antipsychotic and antihistaminic drugs 10,11 . These phenothiazine moieties are widely employed as antibacterial 12 , antiviral 13 , anti-inflammatory 14,15 , anticancer 16,17 , tranquilizers agents 18,19 , antitubercular 20 , anticonvulsant 21 , antiproliferative 22 and as anti-HIV agents 23 . Triazoles and their derivatives established a main class of organic molecules in a broad spectrum of biological activities, various industrial, agricultural and pharmaceutical fields [24][25][26] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antioxidant Evaluation of Novel Phenothiazine Linked Substitutedbenzylideneamino-1,2,4-Triazole Derivatives

Maddila

Momin

Gorle

et al. 2015

J. Chil. Chem. Soc.

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A series of novel 5-((10H-phenothiazin-10yl)methyl)-4-(substitutedbenzylideneamino)-4H-1,2,4-triazole-3-thiol derivatives (6a-i) have been synthesized from compound (1) through a multi-step reaction. The key intermediate (5) afforded a series of title compounds (6a-i) on condensation with various suitable aldehydes in the presence of H 2 SO 4 . The structures of novel compounds were characterized based on their elemental analysis, IR, 1 H-NMR, 13 C-NMR and MS spectral data. All these novel compounds were screened for their in vitro antioxidant activity by employing nitric oxide, hydrogen peroxide, and DPPH radical scavenging assays. The compounds 6d, 6e and 6i demonstrated potent antioxidant activity as these contain the electron-releasing groups.

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2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: Synthesis and Biological evaluation as potential antiproliferative and antifungal agents

Cited by 98 publications

References 33 publications

Recent progress in biological activities of synthesized phenothiazines

Recent progress in biological activities of synthesized phenothiazines

Reactions of 5-oxo-1-phenylpyrrolidine-3-carbohydrazides with 1,4-naphthoquinone derivatives and the properties of the obtained products

Synthesis and Antioxidant Evaluation of Novel Phenothiazine Linked Substitutedbenzylideneamino-1,2,4-Triazole Derivatives

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