2,3,5-Substituted tetrahydrofurans as cancer chemopreventives. Part 1: Synthesis and anti-cancer activities of 5-hydroxymethyl-2,3-diaryl-tetrahydro-furan-3-ols

Singh, Palwinder; Mittal, Anu; Kumar, Subodh

doi:10.1016/j.bmc.2007.04.004

Cited by 18 publications

(12 citation statements)

References 19 publications

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“…In fact, it is the starting material for the synthesis of 2,3,5-substituted tetrahydrofurans (cancer chemopreventives [12] and selective COX-Z inhibitors [13] ) of 4,5-diarylimidaxoles (human CB1 receptor inverse agonists), [14] of 3,4,5-triaryl-1H-pyrroles (antihyperglycemic molecules), [15] etc. Moreover, some substituted benzoins have themselves pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%

Study on the Reactivity of Aldehydes in Electrolyzed Ionic Liquids: Benzoin Condensation – Volatile Organic Compounds (VOCs) vs. Room Temperature Ionic Liquids (RTILs)

et al. 2010

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The benzoin condensation of aromatic and heteroaromatic aldehydes, catalyzed by electrochemically generated N-heterocyclic carbenes, has been set up in the absence of organic solvents and bases. a-Hydroxy ketones have been isolated in good to elevated yields, in short reaction times. Aldol products and carbene-aldehyde adducts have been obtained in elevated yields from linear and short branched aldehydes, respectively. A comparison with the use of classical organic solvents has been reporte

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Section: Introductionmentioning

confidence: 99%

Study on the Reactivity of Aldehydes in Electrolyzed Ionic Liquids: Benzoin Condensation – Volatile Organic Compounds (VOCs) vs. Room Temperature Ionic Liquids (RTILs)

et al. 2010

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“…See Supporting Information for the synthesis procedure of 2‐hydroxy‐1,2‐bis‐(4‐methylsulfanyl‐phenyl)‐ethanone (MTB)18 and details of other materials.…”

Section: Methodsmentioning

confidence: 99%

Benzoin type photoinitiator for free radical polymerization

Esen

Arsu

Silva

et al. 2013

J. Polym. Sci. A Polym. Chem.

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Benzoin, a popular photoinitiator for free radical polymerization of vinyl monomers, was improved by introduction of two methyl thioether substituents. This new benzoin derivative showed an about 50 times higher light absorption in the near-UV spectral region and performed better than the unsubstituted benzoin in polymerization experiments in bulk solutions or films of acrylate monomers when low initiator concentrations are used. Laser flash photolysis, low temperature luminescence experiments and photoproduct studies by mass spectrometry suggest that a slow a-cleavage mechanism (k a ¼ 2.2 Â 10 5 s À1) from the electronic triplet state with a quantum yield of 0.1 is the primary photoreaction to generate the initiating free radicals.

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“…The combined organic layers were dried over Na 2 SO 4 and concentrated in vacuo. The residue was purified by flash column chromatography to give benzoin substrates [87][88][89].…”

Section: Methodsmentioning

confidence: 99%

Oxidation of benzoins to benzils in the presence of porphyrin sensitizers by air and sunlight or visible light

et al. 2013

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In this work, two new aerobic routes are introduced for the oxidation of a variety of benzoins to benzils by using molecular oxygen in the presence of porphyrins as sensitizers, using white light or sunlight in acetonitrile under mild conditions. The methods have a wide range of applications, do not involve cumbersome work-up, exhibit chemoselectivity and proceed under mild reaction conditions. The resulting products are obtained in good yields in a reasonable time.

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2,3,5-Substituted tetrahydrofurans as cancer chemopreventives. Part 1: Synthesis and anti-cancer activities of 5-hydroxymethyl-2,3-diaryl-tetrahydro-furan-3-ols

Cited by 18 publications

References 19 publications

Study on the Reactivity of Aldehydes in Electrolyzed Ionic Liquids: Benzoin Condensation – Volatile Organic Compounds (VOCs) vs. Room Temperature Ionic Liquids (RTILs)

Study on the Reactivity of Aldehydes in Electrolyzed Ionic Liquids: Benzoin Condensation – Volatile Organic Compounds (VOCs) vs. Room Temperature Ionic Liquids (RTILs)

Benzoin type photoinitiator for free radical polymerization

Oxidation of benzoins to benzils in the presence of porphyrin sensitizers by air and sunlight or visible light

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