2-(3,5-Dihydroxyphenyl)-6-Hydroxybenzothiazole Arrests Cell Growth and Cell Cycle and Induces Apoptosis in Breast Cancer Cell Lines

Abstract

2-Arylbenzothiazoles are an important class of bicyclic privileged substructures present in various natural or synthetic compounds that have been shown to possess anticancer, antifungal, antibacterial, anti-inflammatory, and antiallergic activities. This study examined the antiproliferative properties of 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole (DH) and its molecular mechanism of action in human breast cancer MDA-MB-231 cells. DH inhibits the growth of MDA-MB-231 cells with an IC(50) value of 25 μM in a dose/time-dependent manner as measured by the microculture tetrazolium method. Cell cycle analysis by flow cytometry showed that DH-induced growth arrest could be associated to apoptosis in MDA-MB-231 cells.

A Comparative Analysis of 2-(Thiocyanomethylthio)-Benzothiazole Degradation Using Electro-Fenton and Anodic Oxidation on a Boron-Doped Diamond Electrode

“…23°C), the rate of decomposition is slow; however, as the temperature increases, the rate of decomposition also increases [32]; in this study, the batch mode employed provoked a temperature solution of 60°C, 5 International Journal of Photoenergy because of fluid recirculation. In addition, hydrogen peroxide could react with the chloride ions in solution [30], resulting in the formation of chlorine gas and water (8), which would explain the 8% decrease in the chloride concentration in all of the experiments using the blank solution.…”

“…Reemtsma et al [6] achieved an incomplete TCMTB degradation (75%) in an anaerobic and aerobic wastewater treatment pilot plant, yielding mercaptobenzothiazole (MTB), benzothiazole (BT), and hydroxybenzotriazole (OHBT) as the degradation products, which however are harmful compounds that cause dermatitis [7], cell apoptosis [8], and respiratory tract irritation [9], respectively. De Wever et al [10,11] carried out studies to investigate the biodegradation of these compounds and established that MTB is a recalcitrant compound.…”