2, 3, 4-Furantriones

Ashry, El Sayed H. El; Mousaad, A.; Rashed, N.

doi:10.1016/s0065-2725(08)60863-6

Cited by 20 publications

(3 citation statements)

References 236 publications

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“…The special compound class of 2,3,4-furantriones (e.g., dehydroascorbic acid) was also omitted from this review since EIAshry et a1. 22 have published a recent review on this topic. More specific considerations are presented in the individual sections.…”

Section: Scope and Limitations; Methodical Considerationsmentioning

confidence: 92%

Methods for the synthesis of α‐keto esters

Kovács¹

1993

Recl. Trav. Chim. Pays‐Bas

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Section: Scope and Limitations; Methodical Considerationsmentioning

confidence: 92%

Methods for the synthesis of α‐keto esters

Kovács¹

1993

Recl. Trav. Chim. Pays‐Bas

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“…The biological im portance of acyclonucleosides [1][2][3] and C-nucleosides [4][5][6][7][8][9][10][11][12][13][14] attracted our at tention towards the synthesis of acyclo C-nucleoside analogues [15][16][17][18][19][20][21][22][23][24][25] of potential chem othera peutic interest. The acyclonucleosides have been recently classified [1][2][3] according to the type of the glycon rather than the aglycon part.…”

Section: Introductionmentioning

confidence: 99%

4′, x-Seco And 4′,x-4′,5′-Diseco C-Nucleosides From 2-Hydrazino-(3H)- Thieno [2,3-D] Pyrimidin-4-Ones

Hamed

Bader

El-Ashry

2001

Zeitschrift Für Naturforschung B

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Thieno[2,3-d]pyrimidinone, Triazolo[3,4-a]thieno[2,3-d] pyrimidinone, Sugar Hydrazones Cyclization of 2-hydrazino-5,6-dimethyl-3//-thieno[2,3-d]pyrimidin-4-one (1) with acetic acid gave 3,6,7-trim ethyl-l,2,4-triazolo[3,4-a]thieno[2,3-d] pyrimidin-5-one (5) whose Dimroth rearrangement gave 2,6,7-trimethyl-l,2,4-triazolo[3,4-a]thieno[2,3-d]pyrimidin-5-one (11). Alternatively, 5 was obtained from the dehydrogenative cyclization of acetaldehyde 5,6dim ethyl-4-3//-oxo-thieno[2,3-c/]pyrimidin-2-yl hydrazone (7). Reaction of 1 and 2 with a number of sugars gave the respective hydrazones 19 and 20. Those of the D -glucose exist in the cyclic pyranosyl structure in addition to minor amounts of the acyclic structure. Dehydro genative cyclization of the sugar hydrazones gave the respective fused tricyclic compounds 25 and 26.

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“…The versatility of sugar hydrazones and the inherent functionality in their derivatives make them valuable enantiomerically pure synthons for the synthesis of nucleosides, acyclo nucleosides and heterocyclic compounds. [1][2][3][4][5] Hydrazines and hydrazones exhibit important biological activities such as inhibiting oxidases, redox and mitochondrial systems as well as possessing antiviral and antimicrobial activities. As a part of a program directed towards the synthesis of effective anti-hepatits B viral agents (HBV) 10,11 the synthesis and reactions of some sugars hydrazones possessing the 2,4,6-trichlorophenyl group have been studied.…”

mentioning

confidence: 99%