2.28 Plasma levels of soluble CD30 and CD40L in pediatric patients after liver transplantation

Shevchenko, O. P.; Цирульникова, О. М.; Гичкун, О. Е.; Курабекова, Р. М.; Ammosov, A. A.; Gautier, S. V.

doi:10.1515/9783110224641.124

Cited by 2 publications

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“…Immune system activation was evaluated using several plasma immune biomarkers that contribute to the clinical outcome following solid organ transplantation: CRP, a marker of acute phase inflammation , preformed HLA I and II ab antibodies, which are the markers of the activation of the histocompatibility system ; soluble CD40 ligand (sCD40L), a costimulatory molecule of T‐lymphocyte activation ; soluble CD30 (sCD30), a Th2 cell activation marker ; and neopterin, a macrophage activation marker .…”

Section: Methodsmentioning

confidence: 99%

The hematopoietic stem cell number in the peripheral blood of pediatric recipients correlates with the outcome after living donor liver transplantation

Gautier

Shevchenko

Цирульникова

et al. 2015

Pediatric Transplantation

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It has been proposed that circulating HSCs play a role in graft survival after liver transplantation. The aim was to analyze the relationship between the number of HSCs before and after LDLT and liver function, immune biomarkers, and clinical outcomes in pediatric patients. We studied 15 pairs of adult healthy liver donors and pediatric recipients with ESLD. The CD34/CD45+ cell number was measured in the blood via flow cytometry, and plasma levels of immune biomarkers - via ELISA. CD34/CD45+ cell number in the recipients decreased within the first week after LDLT. The cell number before LDLT was negatively correlated with the plasma levels of CRP and the development of graft dysfunction in the early post-transplant period. After LDLT, the CD34/CD45+ cell number was positively correlated with the pretransplant plasma level of sCD40L, a T-cell activation marker. In adult liver donors, the cell number did not change within the first week after liver resection and was lower than in pediatric recipients. The results suggest that in pediatric recipients, the HSC number may be associated with graft function and could be regarded as a potential predictor of the clinical outcome after LDLT.

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Section: Methodsmentioning

confidence: 99%

The hematopoietic stem cell number in the peripheral blood of pediatric recipients correlates with the outcome after living donor liver transplantation

Gautier

Shevchenko

Цирульникова

et al. 2015

Pediatric Transplantation

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“…Объективными критериями функционального восстановления трансплантированной печени и организма в целом являются как рутинные лабораторные показатели, так и новые биомаркеры, отражающие состояние иммунной и других важнейших систем поддержания гомеостаза. В последние годы в трансплантологии большое внимание уделяется изучению роли ключевых молекул, регулирующих иммунный ответ, таких как неоптерин, CD30, лиганд CD40, трансформирующий фактор роста бета 1 (TGF-β1) и другие [2,3]. TGF-β1 является одним из перспективных биомаркеров в трансплантации печени, т. к. играет ключевую роль не только в развитии иммунного ответа [4], но и в процессах регенерации печени [5,6].…”

Section: Abstract: Related Liver Transplantation Immune Biomarkersunclassified

Transforming Growth Factor 1 in Children of Early Age With Liver Transplantation

Курабекова¹,

Шевченко²,

Цирульникова³

et al. 2015

Russian Journal of Transplantology and Artificial Organs

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Отдел регуляторных механизмов в трансплантологии ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва, Российская Федерация 2 ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва, Российская Федерация 3 Кафедра трансплантологии и искусственных органов ГБОУ ВПО «Первый МГМУ им. И.М. Сеченова», Москва, Российская Федерация 4 Отделение хирургическое № 2 ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России,

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2.28 Plasma levels of soluble CD30 and CD40L in pediatric patients after liver transplantation

Cited by 2 publications

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The hematopoietic stem cell number in the peripheral blood of pediatric recipients correlates with the outcome after living donor liver transplantation

The hematopoietic stem cell number in the peripheral blood of pediatric recipients correlates with the outcome after living donor liver transplantation

Transforming Growth Factor 1 in Children of Early Age With Liver Transplantation

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