2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

Wilson, Richard K.; Ainscough, R.; Anderson, Kimberly; Baynes, C.; Berks, Mary; Bonfield, James K.; Burton, Jillian; Connell, Mary A. O'; Copsey, T.; Cooper, John A.; Coulson, Alan; Craxton, Molly; Dear, Simon; Du, Zijin; Durbin, Richard; Favello, Anthony; Fraser, Andrew; Fulton, Lucinda A.; Gardner, Andrew F.; Green, P.; Hawkins, Trevor; Hillier, LaDeana W.; Jier, M.; Johnston, Leland H.; Jones, Matthew C.; Kershaw, J. K.; Kirsten, Janet H.; Laisster, N.; Latreille, Phil; Lightning, J.; Lloyd, Christine; Mortimore, Beverley; O’Callaghan, Maureen; Parsons, Jeremy; Percy, C.; Rifken, L.; Roopra, Avtar; Saunders, Diane G. O.; Shownkeen, Ratna; Sims, Matthew C; Smaldon, N.; Smith, Andrew J.H.; Smith, Michael W.; Sonnhammer, Erik L. L.; Staden, Rodger; Sulston, John; Thierry‐Mieg, Jean; Thomas, Karen; Vaudin, Mark D.; Vaughan, Kevin T.; Waterston, Robert H.; Watson, Andy; Weinstock, L A; Wilkinson-Sproat, J.; Wohldman, P.

doi:10.1038/368032a0

Cited by 1,476 publications

(766 citation statements)

References 39 publications

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“…Identical residues are shadowed in dark grey whereas similar residues are in light grey. CNEU is the neuralized homolog of Caenorhabditis elegans (Wilson and al., 1994); DNEU is neuralized from Drosophila melanogaster (Boulianne et al, 1991); IAP homologs are from the following species: IAPC, Cydia pomonella granulosis virus (Crook et al, 1993); IAPO, Orgyia pseudotsugata nuclear polyhedrosis virus (Birnbaum et al, 1994); IAPA, Autographa californica nuclear polyhedrosis virus (Ayres et al, 1994); DIAP, Drosophila melanogaster (Liston et al, 1996); XIAP, HIAP1 and HIAP2, Homo sapiens (Liston et al, 1996) and MIAP2, Mus musculus (Rothe et al, 1995) Fingers: what for?…”

Section: The Central Acidic Domain: a Link With Translation?mentioning

confidence: 99%

Mdm2: keeping p53 under control

1997

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The Mdm2 gene is overexpressed in several human tumors. The oncogenic potential of Mdm2 is partially explained by the inhibition of the activity of the tumor suppressor protein p53. Determination of the threedimensional structure of complexes between Mdm2 and the N-terminal p53 peptide provided a molecular basis for the inhibition of the transcriptional function of p53 by Mdm2. More dramatically, p53 is targeted by Mdm2 for rapid degradation. The Mdm2 gene itself is activated by p53, which gives the opportunity for feed-back control of p53 activity. Keeping p53 under control is most likely the major task of Mdm2 during early development. Recently, evidence was provided for an alternative, p53-independent function of Mdm2.

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Section: The Central Acidic Domain: a Link With Translation?mentioning

confidence: 99%

Mdm2: keeping p53 under control

1997

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“…For the three sequences that we have determined to be ampli®ed and overexpressed, only Cda1bc08 has an open reading frame of su cient length to provide meaningful results from a homology search. This expressed sequence displays signi®cant homology with the putative gene for 4-nitrophenylphosphatase of C. elegans (Wilson et al, 1994). However, no relationship between the activity of such a protein and cell proliferation is readily apparent.…”

Section: Discussionmentioning

confidence: 96%

Analysis of EGF receptor amplicons reveals amplification of multiple expressed sequences

et al. 1998

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“…It was shown previously that the product of a predicted gene from chromosome III of C. elegans had 30 to 40% similarity with FGFs from other species (Wilson et al, 1994;Coulier et al, 1997). A screening of the nematode sequences (The C. elegans Sequencing Consortium, 1998), revealed just one other C. elegans fgf, on chromosome X, already identi®ed as egl-17 (Burdine et al, 1997(Burdine et al, , 1998.…”

Section: Discussionmentioning

confidence: 97%

let-756, a C. elegans fgf essential for worm development

et al. 1999

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In vertebrates, Fibroblast Growth Factors (FGFs) and their receptors are involved in various developmental and pathological processes, including neoplasia. The number of FGFs and their large range of activities have made the understanding of their precise functions di cult. Investigating their biology in other species might be enlightening. A sequence encoding a putative protein presenting 30 ± 40% identity with the conserved core of vertebrate FGFs has been identi®ed by the C. elegans sequencing consortium. We show here that this gene is transcribed and encodes a putative protein of 425 amino acids (aa). The gene is expressed at all stages of development beyond late embryogenesis, peaking at the larval stages. Loss-of-function mutants of the let-756 gene are rescued by the wild type fgf gene in germline transformation experiments. Two partial loss-of-function alleles, s2613 and s2809, have a mutation that replaces aa 317 by a stop. The truncated protein retains the FGF core but lacks a C-terminus portion. These worms are small and develop slowly into clear and scrawny, yet viable and fertile adults. A third allele, s2887, is inactivated by an inversion that disrupts the ®rst exon. It causes a developmental arrest early in the larval stages. Thus, in contrast to the other nematode fgf gene egl-17, let-756/fgf is essential for worm development.

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2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

Cited by 1,476 publications

References 39 publications

Mdm2: keeping p53 under control

Mdm2: keeping p53 under control

Analysis of EGF receptor amplicons reveals amplification of multiple expressed sequences

let-756, a C. elegans fgf essential for worm development

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