2,2-Dimethylchromenes from Eupatorium aschembornianum

Gómez, F.; Quijano, Leovigildo; Calderón, José S.; Perales, Aurea; Ríos, Tirso

doi:10.1016/0031-9422(82)83051-3

Cited by 21 publications

(14 citation statements)

References 7 publications

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“…Thus, the structure of 2 was established as 5-acetyl-3b-angeloyloxy-2b-(1-hydroxyisopropyl)-6-methoxy-2,3-dihydrobenzofurane. The 1 H-and 13 C-NMR data [6], [7], [8] and the HMQC and HMBC correlations for 1 and 2 are in accordance with those of other benzofurane compounds.…”

supporting

confidence: 74%

Two New Benzofuranes fromEupatorium aschenbornianumand their Antimicrobial Activity

2003

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Through a bioassay-guided fractionation, from the aerial parts of the medicinal plant Eupatorium aschenbornianum were isolated two new benzofurane compounds, 5-acetyl-3beta-angeloyloxy-2beta-(1-hydroxyisopropyl)-2,3-dihydrobenzofurane ( 1) and 5-acetyl-3beta-angeloyloxy-2beta-(1-hydroxyisopropyl)-6-methoxy-2,3-dihydrobenzofurane ( 2) in addition to 4-hydroxy-3,5-diprenylacetophenone, espeletone ( 3), encecalinol ( 4), beta-sitosterol and stigmasterol. The antimicrobial evaluation of these natural products showed that 1 [MIC = 200 microg/mL against T. mentagrophytes and 100 microg/mL against T. rubrum], 2 [MIC = 50 microg/mL towards both] and 3 [MIC = 100 microg/mL against both] were active against dermatophytes, while 4 was active against all of microorganisms assayed [MIC = 12.5 microg/mL ( T. mentagrophytes), 12.5 microg/mL ( T. rubrum), 100 microg/mL ( C. albicans) and 200 microg/mL ( A. niger)].

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supporting

confidence: 74%

Two New Benzofuranes fromEupatorium aschenbornianumand their Antimicrobial Activity

2003

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“…A chemical study showed the presence of chromones in the extract of this plant. Other compounds belonging to the benzofurane group [4,5] have also been identified. Microbiological studies have shown that extracts of A. pichinchensis possess significant antifungal activity, especially in Trichophyton rubrum and Trichophyton menthagrophytes strains [6].…”

mentioning

confidence: 99%

Effect on the Wound Healing Process andIn VitroCell Proliferation by the Medicinal Mexican PlantAgeratina pichinchensis

et al. 2011

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The species Ageratina pichinchensis (Asteraceae) has been used for a long time in Mexican traditional medicine for the treatment of different skin conditions and injuries. In this study, the healing capacity of the plant extracts obtained was evaluated and, in order to understand the mechanism of healing, we also analyzed its effect on cell proliferation IN VITRO, cytotoxicity, and skin irritation. Different extracts obtained from the aerial parts of A. pichinchensis, topically administrated, were evaluated in a healing model by scalpel-blade incision on the rat. The extracts, at 10 % concentrations, were administrated daily during an eight-day period. A control group, to which the vehicle was administered, was used; while fibrinolysin (Fibrase SA®) was administered for positive control purposes. Reduction in wound size and the histological characteristics of the skin at the end of the treatment were evaluated. Cytotoxicity was evaluated in cell lines KB (nasopharyngeal carcinoma), UISO (squamous cell carcinoma of the cervix), OVCAR (ovarian carcinoma), and HCT-15 (colon carcinoma). In addition, the effect on cell proliferation of cell line MRC-5 (normal cells from human fetal lung) was measured, and skin irritation was evaluated. The results showed an important healing capacity of A. pichinchensis extract in noninfected wounds; the aqueous extract was found to be the most efficient. The extracts exhibited no cytotoxic effect; however, there was an effect that promoted cell proliferation in cell line MRC-5. The products tested demonstrated no skin irritant effects.

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“…Regarding the use of this remedy, no toxicological reports have been found, while local healers stated that the product did not produce considerable skin irritation [2], [3], [4]. Two chemical compounds were identified in A. pichinchensis: 2,2-dimethylchromone, and dimethoxyargerochromone, which are biologically active chromones that are able to modify insect reproductive hormones [5]. Navarro et al reported that the ethanol extract from A. pichinchensis leaves possesses antifungal activity [6].…”

mentioning

confidence: 99%

Double-Blind Clinical Trial for Evaluating the Effectiveness and Tolerability ofAgeratina pichinchensisExtract on Patients with Mild to Moderate Onychomycosis. A Comparative Study with Ciclopirox

et al. 2008

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Aerial parts of AGERATINA PICHINCHENSIS have been used, in Mexican traditional medicine, as a remedy for the treatment of skin mycosis. Onychomycosis, also known as tinea of the nails or tinea unguium, constitutes an infection of the nails produced by dermatophytes. Clinically, onychomycosis is manifested by changes on the color, texture and thickness of the nail. The agent most frequently found in this disease is TRICOPHYTON RUBRUM. The present study evaluated the therapeutic effectiveness and tolerability of topical administration of A. PICHINCHENSIS extract on the nails of patients with the clinical and mycological diagnosis of onychomycosis. A phytopharmaceutical formulation was developed in a lacquer solution containing the standardized (encecalin) extract of A. PICHINCHENSIS. A similar lacquer solution containing 8 % ciclopirox was used as control. Treatments were assigned randomly and administered topically for 6 months. Ninety six patients concluded the study (49 in the experimental group and 47 in the control); 71.1 % of patients from the experimental and 80.9 % from the control group showed therapeutic effectiveness, while 59.1 % and 63.8 % from the experimental and control group, respectively, achieved mycological effectiveness. Therapeutic success was observed in 55.1 and 63.8 %, respectively. No patient exhibited intense side effects. Statistical analysis demonstrated no differences between treatments.

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2,2-Dimethylchromenes from Eupatorium aschembornianum

Cited by 21 publications

References 7 publications

Two New Benzofuranes fromEupatorium aschenbornianumand their Antimicrobial Activity

Two New Benzofuranes fromEupatorium aschenbornianumand their Antimicrobial Activity

Effect on the Wound Healing Process andIn VitroCell Proliferation by the Medicinal Mexican PlantAgeratina pichinchensis

Double-Blind Clinical Trial for Evaluating the Effectiveness and Tolerability ofAgeratina pichinchensisExtract on Patients with Mild to Moderate Onychomycosis. A Comparative Study with Ciclopirox

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