2,2-Dihydroxyindane-1,3-dione

Abstract

Schiff bases and complexes are today the subject of many studies because of the established biological, inhibitor and catalytic properties. The aim of this paper is to investigate the interaction of Schiff base obtained by reaction of 2,2-dihydroxyindane-1,3-dione (ninhydrin) and the essential amino acid tryptophan with copper(II) ion. Spectral characterization and examination of the potential antimicrobial and antioxidant activity of the synthesized complex were performed. The imine Cu(II) complex is characterized by FTIR and UV/Vis spectroscopy. Stoichiometric M:L ratio was determined by Joe and Yones method. Antioxidant activity was tested by DPPH and FRAP method. Antibacterial and antifungal activity was determined by diffusion technique on reference strains from the ATCC collection. The results showed that the synthesized Schiff base coordinates the Cu(II) ion as a tridentate ligand, in a molar ratio of 1:2 (M:L). The synthesized complex showed significant antioxidant activity. The antimicrobial effect of the Cu(II) complex in the case of S. aureus, E. faecalis, L. monocytogenes, B. subtilis and C. albicans was obtained, with inhibition zones of 11-20 mm.