2,2′-carbonyl-bis(3,5-dioxo-4-methyl-1,2,4-oxadiazolidine): I-A new reagent for the preparation of carbamates and amides, application to the synthesis of dipeptides.

Denarié, Michel; Grehouillat, Denis; Malfroot, Thierry; Senet, J.‐P. G.; Sennyey, G.; Wolf, P. R.

doi:10.1016/s0040-4039(01)81064-9

Cited by 16 publications

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References 7 publications

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“…In this context, several new alkoxycarbonylating agents ( 7 – 11 ) based on mixed carbonates have been developed (Figure ). These methods are often used for the synthesis of carbamates in drug design. − …”

Section: Methods For the Synthesis Of Carbamatesmentioning

confidence: 99%

Organic Carbamates in Drug Design and Medicinal Chemistry

2015

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The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many carbamate derivatives are specifically designed to make drug-target interactions through their carbamate moiety. In this review, we present properties and stabilities of carbamates, reagents and chemical methodologies for the synthesis of carbamates, and recent application of carbamates in drug design and medicinal chemistry.

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Section: Methods For the Synthesis Of Carbamatesmentioning

confidence: 99%

Organic Carbamates in Drug Design and Medicinal Chemistry

2015

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“…295 showed herbicidal and plant growth-retarding activities in pre-and postemergence treatments of a wide variety of weeds. 2,2O-Carbonyl-bis(3,5-dioxo-4-methyl-1,2,4-dioxazolidine) (acronym: COMODD), a symmetrical non-hygroscopic equivalent of 1,1O-carbonyldiimidazole (CDI) [223], has been employed for the synthesis of the insecticide Aldicarb in 85% yield, avoiding use of the noxious isocyanate [224] and following a proven general reaction route for this phosgene equivalent. The same authors studied the synthesis of 2-alkoxy-5-n-propyl-or 2-alkoxy-5-secbutylphenyl methylcarbamates as active intermediates for insecticides [218].…”

Section: Isouronmentioning

confidence: 99%