2-(2,4-Dichlorophenoxy) phenylacetic acid (fenclofenac): one of a novel series of anti-inflammatory compounds with low ulcerogenic potential

Atkinson, David; Godfrey, Kayla; Jordan, B J; Leach, E C; Meek, B.; Nichols, J. Doland; Saville, John F.

doi:10.1111/j.2042-7158.1974.tb09289.x

Cited by 19 publications

(5 citation statements)

References 2 publications

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“…A preliminary account of its anti-inflammatory and related properties has been published elsewhere [2]; the present paper updates and expands the findings presented.…”

Section: Introductionsupporting

confidence: 55%

Anti-inflammatory and related properties of 2-(2,4-dichlorophenoxy)phenylacetic acid (fenclofenac)

Atkinson

Leach

1976

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Fenclofenac was shown to possess anti-inflammatory, antinociceptive and antipyretic properties as measured by tests in rats that detect clinically active compounds. In a chronic test for assessing anti-inflammatory activity (established adjuvant arthritis), it was approximately equipotent to alclofenac, fenoprofen calcium and phenylbutazone, more potent than acetylsalicylic acid and ibuprofen, but was less potent than diclofenac sodium, indomethacin, ketoprofen and naproxen. In contrast, the potency of fenclofenac in acute tests for anti-inflammatory, antinociceptive and anti-pyretic activity was generally lower, the drug being approximately equipotent to acetylsalicylic acid in such tests. The anti-inflammatory activity of fenclofenac was not mediated via the pituitary-adrenal axis or a counter-irritant action. Fenclofenac was shown to have remarkably low gastric ulcerogenic potential, both acutely and chronically.

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“…A preliminary account of its anti-inflammatory and related properties has been published elsewhere [2]; the present paper updates and expands the findings presented.…”

Section: Introductionsupporting

confidence: 55%

Anti-inflammatory and related properties of 2-(2,4-dichlorophenoxy)phenylacetic acid (fenclofenac)

Atkinson

Leach

1976

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“…An aryl ethers have a medicinal importance [1], some derivatives are considered non-steroid anti-inflammatory [2], such as fenclofenac [3], which is considerd from diclofenac group and has similar pharmacological properties as anti-arthritis [4]. There are several ways to synthesis of aryl ethers is typically achieved via a nucleophilic aromatic substitution (NAS) process or transition metal catalyzed Ullmann-type [5,6] and Hartwig [7,8] or Buchwald-type [9,10] O-arylation reactions.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Structure of New Compounds NSAIDs-Like Using a Heterogeneous Recyclable Catalyst

Alkayal

Keshe

Madwar

et al. 2016

ILCPA

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In this research, Phenol derivatives have been reacted with aryl halides using 5 mol% Cu(I) Complex [CuClPPh3]4 as catalyst supported on Amberlyst A21. The typical reaction has been performed between p-cresol and bromobenzene. This reaction is achieved in o-xylene as solvent. However, the catalyst complex does not dissolve in o-xylene rather it acts as heterogeneous catalyst. Therefore, it is filtrated at the end of the reaction and reused several times. Accordingly, new compounds were prepared by reacting some of bromoaryl derivatives with some Phenol derivatives. It is anticipated that the synthesized compounds have a structure NSAIDs-likes that may find their applications in the pharmaceutical industries.

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“…It was, therefore, of interest to determine whether fenclofenac, a recently developed nonsteroidal anti-inflammatory agent [8,9], inhibited prostaglandin production and to ascertain whether such activity could account for its antiinflammatory properties. For this purpose, studies have been undertaken to see if fenclofenac lowers prostaglandin levels in rat inflammatory exudate and to compare such activity with that of standard drugs.…”

Section: Introductionmentioning

confidence: 99%

Effect of fenclofenac on prostaglandin production in carageenin air bleb exudates in rats

Atkinson

Leach

1978

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Employing a modified carrageenin air bleb technique in rats, the effect was studied of fenclofenac and standard drugs (acetylsalicylic acid, indomethacin and phenylbutazone) on prostaglandin production in inflammatory exudate. In common with the standard drugs, fenclofenac reduced exudate prostaglandin levels, being approximately equipotent with phenylbutazone in this respect. Also, an attempt was made to relate the effect of fenclofenac and standard drugs on prostaglandins to their acute anti-inflammatory activity as determined in a modified carrageenin paw oedema test in rats. Whilst acetylsalicylic acid and phenybutazone significantly inhibited oedema at doses producing 80% inhibition of prostaglandin production in air bleb exudate, fenclofenac and indomethacin did not. The overall results were considered to support the view expressed by other workers that the acute anti-inflammatory activity of acidic anti-inflammatory agents does not result solely, if at all, from inhibition of prostaglandin synthesis.

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2-(2,4-Dichlorophenoxy) phenylacetic acid (fenclofenac): one of a novel series of anti-inflammatory compounds with low ulcerogenic potential

Cited by 19 publications

References 2 publications

Anti-inflammatory and related properties of 2-(2,4-dichlorophenoxy)phenylacetic acid (fenclofenac)

Anti-inflammatory and related properties of 2-(2,4-dichlorophenoxy)phenylacetic acid (fenclofenac)

Synthesis and Structure of New Compounds NSAIDs-Like Using a Heterogeneous Recyclable Catalyst

Effect of fenclofenac on prostaglandin production in carageenin air bleb exudates in rats

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